Results 101 to 110 of about 5,736 (234)
Epilepsia, Volume 66, Issue 11, Page 4538-4553, November 2025.Abstract Objective Mutations of the DEP Domain Containing 5 gene (DEPDC5), a mechanistic Target of Rapamycin (mTOR) inhibitor involved in amino acid sensing, are associated with neurological diseases such as epilepsy and/or autism spectrum disorder (ASD). Loss of DEPDC5 impacts early neuronal development via mTOR hyperactivity.
Mattson S. O. Jones +14 more
wiley +1 more source
From Heteroaromatic acids and Imines to Azaspirocycles : Stereoselective Synthesis and 3D Shape Analysis [PDF]
, 2016 Heteroaromatic carboxylic acids have been directly coupled with imines using T3P and NEt(i-Pr)2 to form azaspirocycles via intermediate N-acyliminium ions.
Bailey +65 more
core +2 more sources
Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites [PDF]
Science Signaling, 2014 Analysis of the metabolome of yeast grown in nutrient-poor conditions reveals a key role for Npr2 and TORC1 signaling complexes in regulating the use of glutamine as a nitrogen source.
Sunil, Laxman +3 more
openaire +2 more sources
Phosphodiesterase 3 inhibitors boost bone outgrowth
British Journal of Pharmacology, Volume 182, Issue 18, Page 4327-4342, September 2025.Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe +11 more
wiley +1 more source
Whole exome sequencing to identify genetic causes of short stature [PDF]
, 2014 BACKGROUND/AIMS: Short stature is a common reason for presentation to pediatric endocrinology clinics. However, for most patients, no cause for the short stature can be identified.
Dauber, Andrew +6 more
core +1 more source
GADD45A is Essential for Granulosa Cells Differentiation and Ovarian Reserve in Human and Mice
Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.ABSTRACT Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in DOR pathogenesis remains unexplored. We employed transcriptome sequencing, qPCR and Western Blot analyses
Juncen Guo +13 more
wiley +1 more source
Development of Advanced High Lift Leading Edge Technology for Laminar Flow Wings [PDF]
, 2013 This paper describes the Advanced High Lift Leading Edge (AHLLE) task performed by Northrop Grumman Systems Corporation, Aerospace Systems (NGAS) for the NASA Subsonic Fixed Wing project in an effort to develop enabling high-lift technology for laminar ...
Bright, Michelle M. +3 more
core +1 more source
Advanced Science, Volume 12, Issue 30, August 14, 2025.RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang +7 more
wiley +1 more source
, 1993 We investigate recent claims concerning a new class of cosmic string solutions in the Weinberg-Salam model. They have the general form of previously discussed semi-local and electroweak strings, but are modified by the presence of a non-zero W-condensate
A. Achúcarro +12 more
core +1 more source
A tudor domain protein SPINDLIN1 interacts with the mRNA-binding protein SERBP1 and is involved in mouse oocyte meiotic resumption [PDF]
, 2013 Mammalian oocytes are arrested at prophase I of meiosis, and resume meiosis prior to ovulation. Coordination of meiotic arrest and resumption is partly dependent on the post-transcriptional regulation of maternal transcripts.
A Goncalves Kde +43 more
core +3 more sources