Deletion mutant of Irx3/5 shows the cochlear base fused with the saccule, whereas in wild‐type mice, the saccule is separated from the base by the ductus reuniens. Irx3 and Irx5 are potential evolutionary branch‐point genes necessary for balance‐sound segregation.
Bernd Fritzsch+7 more
wiley +1 more source
Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology
In vitro maturation (IVM) is a promising assisted reproductive technology (ART) for human infertility treatment. However, when cumulus oocyte complexes (COCs) are removed from their follicular environment when manipulated in vitro, it can lead to a ...
Christie L Sun+3 more
doaj +1 more source
Data reduction formulas for the 16-foot transonic tunnel: NASA Langley Research Center, revision 2 [PDF]
The equations used by the 16-Foot Transonic Wind Tunnel in the data reduction programs are presented in nine modules. Each module consists of equations necessary to achieve a specific purpose.
Berrier, Bobby L.+3 more
core +1 more source
Unstable GRB photospheres and electron-positron annihilation lines
We propose an emission mechanism of prompt gamma-ray bursts (GRBs) that can reproduce the observed non-thermal spectra with high radiative efficiencies, >50%. Internal dissipation below a photosphere can create a radiation-dominated thermal fireball.
Kenji Toma+7 more
core +1 more source
Regulation and Function of C-Type Natriuretic Peptide (CNP) in Gonadotrope-Derived Cell Lines
C-type natriuretic peptide (CNP) is the most conserved member of the mammalian natriuretic peptide family, and is implicated in the endocrine regulation of growth, metabolism and reproduction.
Samantha M Mirczuk+11 more
doaj +1 more source
Novel variants in natriuretic peptide receptor 2 in unrelated patients with acromesomelic dysplasia type Maroteaux [PDF]
Acromesomelic dysplasia are a heterogeneous group of disorders with variable spectrum and severity of skeletal anomalies in the affected individuals. Acromesomelic dysplasia type Maroteaux (AMDM) is characterized by extreme shortening of the forelimbs ...
Ahmed, Sufian+6 more
core +1 more source
Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3 [PDF]
A cyclic GMP (cGMP) signaling pathway, comprising C-type natriuretic peptide (CNP), its guanylate cyclase receptor Npr2, and cGMP-dependent protein kinase I, is critical for the bifurcation of dorsal root ganglion (DRG) and cranial sensory ganglion axons
Feil, R.+5 more
core +1 more source
Familial idiopathic short stature and beyond: a case-report of a novel heterozygous NPR2 mutation.
Background: NPR2 gene encodes for B-type natriuretic peptide receptor (NPR-B), a positive regulator of the growth plate. Recently, heterozygous NPR2 mutations were reported in 2–6% cases of idiopathic short stature (ISS) and 13.6% of familial ISS ...
Ylenia Giorgianni+5 more
doaj +1 more source
In vitro embryo production success in juvenile animals is compromised due to their intrinsic lower oocyte quality. Conventional in vitro maturation (IVM) impairs oocyte competence by inducing spontaneous meiotic resumption.
Sandra Soto-Heras+5 more
doaj +1 more source
Applications of thermal energy storage in the cement industry [PDF]
In the manufacture of cement, literally trillions of Btu's are rejected to the environment each year. The purpose of this feasibility study program was to determine whether thermal energy storage could be used to conserve or allow alternative uses of ...
Beshore, D. G.+3 more
core +1 more source