Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two-Sample Mendelian Randomization Analysis. [PDF]
Int J HypertensBackground: Preeclampsia, a pregnancy complication marked by hypertension after 20 weeks of gestation, arises from placental factors that impair maternal vascular function. C‐type natriuretic peptide (CNP), known for its vasodilatory role, may help counter preeclampsia‐related vascular dysfunction.
Harpe R +6 more
europepmc +6 more sources
The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord [PDF]
The Journal of Cell Biology, 2007 Sensory axonal projections into the spinal cord display a highly stereotyped pattern of T- or Y-shaped axon bifurcation at the dorsal root entry zone (DREZ). Here, we provide evidence that embryonic mice with an inactive receptor guanylyl cyclase Npr2 or
Buttgereit, J. +7 more
core +7 more sources
eLife, 2017 Activating mutations in fibroblast growth factor (FGF) receptor 3 and inactivating mutations in the NPR2 guanylyl cyclase both cause severe short stature, but how these two signaling systems interact to regulate bone growth is poorly understood. Here, we
Leia C Shuhaibar +13 more
doaj +7 more sources
Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP [PDF]
Nature Communications, 2018 Natriuretic peptides (NPs) are important hormones that regulate cardiovascular physiology by increasing cGMP levels in cardiomyocytes. Here the authors use scanning ion conductance microscopy and a cGMP FRET sensor to identify a differential localisation
Hariharan Subramanian +5 more
doaj +9 more sources
Mutation of Npr2 leads to blurred tonotopic organization of central auditory circuits in mice. [PDF]
PLoS Genetics, 2014 Tonotopy is a fundamental organizational feature of the auditory system. Sounds are encoded by the spatial and temporal patterns of electrical activity in spiral ganglion neurons (SGNs) and are transmitted via tonotopically ordered processes from the ...
Cindy C Lu +5 more
doaj +7 more sources
Heterozygous NPR2 Mutation in Two Family Members with Short Stature and Skeletal Dysplasia [PDF]
Case Reports in Endocrinology, 2018 Endochondral ossification at the level of the growth plate, an essential process involved in longitudinal growth, is regulated by hormonal and local factors including C-type natriuretic peptide and its receptor, natriuretic peptide receptor B.
Marianne Jacob +3 more
doaj +5 more sources
Bifurcation of axons from cranial sensory neurons is disabled in the absence of Npr2-induced cGMP signaling [PDF]
The Journal of Neuroscience, 2014 Axonal branching is a prerequisite for the establishment of complex neuronal circuits and their capacity for parallel information processing. Previously, we have identified a cGMP signaling pathway composed of the ligand C-type natriuretic peptide (CNP),
Rathjen, F.G. +2 more
core +6 more sources
Macrophage colony-stimulating factor (M-CSF) is an intermediate in the process of luteinizing hormone-induced decrease in natriuretic peptide receptor 2 (NPR2) and resumption of oocyte meiosis [PDF]
Journal of Ovarian Research, 2017 Background Luteinizing hormone (LH) regulation of the ligand, natriuretic peptide precursor type C, and its receptor, natriuretic peptide receptor 2 (NPR2), is critical for oocyte maturation; however, the mechanism is not fully understood.
Wenchao Sun +6 more
doaj +2 more sources
The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast. [PDF]
PLoS ONE, 2016 In mammalian cells, mTORC1 activity is regulated by Rag GTPases. It is thought that the Ragulator complex and the GATOR (GAP activity towards Rags) complex regulate RagA/B as its GDP/GTP exchange factor (GEF) and GTPase-activating protein (GAP ...
Ning Ma +4 more
doaj +3 more sources
Novel NPR2 Gene Mutations Affect Chondrocytes Function via ER Stress in Short Stature
Cells, 2022 Natriuretic peptide receptor 2 (NPR2) plays a key role in cartilage and bone morphogenesis. The NPR2 gene mutations result in acromesomelic dysplasia, Maroteaux type (AMDM), short stature with nonspecific skeletal abnormalities (SNSK), and epiphyseal ...
Qiuyue Li +9 more
doaj +3 more sources