Results 31 to 40 of about 4,503 (200)
Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites [PDF]
Science Signaling, 2014 Analysis of the metabolome of yeast grown in nutrient-poor conditions reveals a key role for Npr2 and TORC1 signaling complexes in regulating the use of glutamine as a nitrogen source.
Sunil Laxman +3 more
openalex +3 more sources
Heterozygous Mutations in Natriuretic Peptide Receptor-B (NPR2) Are Associated with Short Stature [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2006 C-type natriuretic peptide (CNP) is an important regulator of skeletal growth. Loss-of-function mutations affecting the CNP receptor natriuretic peptide receptor-B (gene NPR2) cause the autosomal recessive skeletal dysplasia, acromesomelic dysplasia, Maroteaux type (AMDM).
Robert C. Olney +6 more
openalex +4 more sources
HeterozygousNPR2Mutations Cause Disproportionate Short Stature, Similar to Léri-Weill Dyschondrosteosis [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2015 SHOX mutations have been detected in approximately 70% of Léri-Weill dyschondrosteosis (LWD) and approximately 2.5% of idiopathic short stature (ISS) cases, suggesting the implication of other genes or loci. The recent identification of NPR2 mutations in ISS suggested that NPR2 mutations may also be involved in disproportionate short stature.The ...
Alfonso Hisado-Oliva +13 more
openalex +4 more sources
C-type natriuretic peptide promotes human granulosa cell growth and estradiol production: Implications for early follicle development. [PDF]
Reprod Med BiolThis study demonstrated that CNP stimulates human granulosa cell proliferation and the potential for cross‐talk between these cells and oocytes. Further research on the simultaneous administration of CNP and E2 may offer a potential avenue for promoting early‐stage follicle development in infertility treatments for patients with poor ovarian reserve ...
Sato Y, Kawamura K.
europepmc +2 more sources
MiR-331-3p facilitates osteoporosis and may promote osteoporotic fractures by modulating NRP2 expression [PDF]
Journal of Orthopaedic Surgery and ResearchBackground Osteoporosis (OP) is a high-incidence bone disease that is prone to osteoporotic fractures (OF), so it has attracted widespread attention. Aim This study investigated the specific expression and role of miR-331 in patients with OP and OF.
Cikedaoerji Na +2 more
doaj +2 more sources
Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase regulates oocyte meiotic resumption [PDF]
BMC Pharmacology and Toxicology, 2015 Background The meiotic cell cycle of mammalian oocytes starts during embryogenesis and then pauses until luteinizing hormone (LH) restarts the cycle. This meiotic arrest is maintained by cGMP, which is produced in the granulosa cells by C-type natriuretic peptide (CNP) activation of NPR2 [1].
Lincoln R. Potter +5 more
core +4 more sources
Molecular Biology of the Cell, 2011 Autophagy is an evolutionarily conserved pathway for the degradation of intracellular contents. How autophagy is regulated, especially upon changes in metabolic and nutritional state, remains poorly understood. By using a prototrophic strain of Saccharomyces cerevisiae, we observed that, unexpectedly, autophagy is strongly induced simply upon switch ...
Xi Wu, Benjamin P. Tu
openalex +4 more sources
Defective development and microcirculation of intestine in Npr2 mutant mice [PDF]
Scientific Reports, 2020 AbstractIntractable gastrointestinal (GI) diseases often develop during infancy. Our group previously reported that natriuretic peptide receptor B (NPR-B)-deficient Npr2slw/slw mice exhibit severe intestinal dysfunction, such as stenosis and distention, which resembles the dysfunction observed in Hirschsprung’s disease-allied disorders.
Masatoshi Hori +7 more
openaire +3 more sources
Heterozygous NPR2 Variants in Idiopathic Short Stature
Genes, 2022 Heterozygous variants in the NPR2 gene, which encodes the B-type natriuretic peptide receptor (NPR-B), a regulator of skeletal growth, were reported in 2–6% cases of idiopathic short stature (ISS). Using next-generation sequencing (NGS), we aimed to assess the frequency of NPR2 variants in our study cohort consisting of 150 children and adolescents ...
Lana Stavber +9 more
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2022 The natriuretic peptide receptors NPR1 and NPR2, also known as guanylyl cyclase A and guanylyl cyclase B, have critical functions in many signaling pathways, but much remains unknown about their localization and function in vivo. To facilitate studies of
Jeremy R. Egbert +13 more
doaj +1 more source