Results 41 to 50 of about 4,503 (200)

NPR2 is involved in FSH-mediated mouse oocyte meiotic resumption [PDF]

Journal of Ovarian Research, 2016
Previous studies have reported that follicle-stimulating hormone (FSH) is often added to culture media to induce oocyte meiotic resumption and maturation and to improve subsequent embryonic development during in vitro maturation (IVM). However, the underlying mechanisms remain unclear.Cumulus-oocyte complexes (COCs) were collected from ovaries 46-48 h ...
Lei Yang, Qiang Wei, Wei Li, Qihui Xi, Xiaoe Zhao, Baohua Ma   +5 more
openalex   +3 more sources

An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene. [PDF]

PLoS ONE, 2012
We describe a three-generation family with tall stature, scoliosis and macrodactyly of the great toes and a heterozygous p.Val883Met mutation in Npr2, the gene that encodes the CNP receptor NPR2 (natriuretic peptide receptor 2). When expressed in HEK293A
Kohji Miura, Noriyuki Namba, Makoto Fujiwara, Yasuhisa Ohata, Hidekazu Ishida, Taichi Kitaoka, Takuo Kubota, Haruhiko Hirai, Chikahisa Higuchi, Noriyuki Tsumaki, Hideki Yoshikawa, Norio Sakai, Toshimi Michigami, Keiichi Ozono   +13 more
doaj   +1 more source

NPR2 Variants Are Frequent among Children with Familiar Short Stature and Respond Well to Growth Hormone Therapy [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2020
Abstract Context The C-type natriuretic peptide receptor encoded by the NPR2 gene is a paracrine regulator of the growth plate; heterozygous NPR2 variants cause short stature with possible presence of different signs of bone dysplasia.
Lukáš Plachý, Petra Dušátková, Klára Maratová, Lenka Petruželková, D Zemková, Lenka Elblová, Petra Kučerová, Ledjona Toni, Stanislava Koloušková, Marta Šnajderová, Zdenĕk Šumnı́k, Jan Lebl, Štěpánka Průhová   +12 more
openalex   +4 more sources

Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth

JCI Insight, 2021
Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase both result in decreased production of cyclic GMP in chondrocytes and severe short stature ...
Leia C. Shuhaibar, Nabil Kaci, Jeremy R. Egbert, Thibault Horville, Léa Loisay, Giulia Vigone, Tracy F. Uliasz, Emilie Dambroise, Mark R. Swingle, Richard E. Honkanen, Martin Biosse Duplan, Laurinda A. Jaffe, Laurence Legeai-Mallet   +12 more
doaj   +1 more source

Short Stature is Progressive in Patients with Heterozygous NPR2 Mutations

The Journal of Clinical Endocrinology & Metabolism, 2020
Abstract Background NPR2 encodes atrial natriuretic peptide receptor B (ANPRB), a regulator of skeletal growth. Biallelic loss-of-function mutations in NPR2 result in acromesomelic dysplasia Maroteaux type (AMDM; OMIM 602875), while heterozygous mutations may account for 2% to 6% of idiopathic short ...
Patrick C Hanley, Corine Martineau, Harsh S Kanwar, Michael A. Levine, Michael A. Levine   +4 more
openaire   +4 more sources

Funktionen der partikulären Guanylatzyklase NPR2 in der Schmerzverarbeitung [PDF]

, 2021
Viele Studien konnten nachweisen, dass die Produktion von cGMP eine entscheidende Funktion im nozizeptiven System einnimmt. Hierbei wurde vor allem die cGMP-Produktion über lösliche Guanylatzyklasen untersucht. Welche Rolle die partikulären Guanlyatzyklasen bei der Entstehung von Schmerzen haben ist weitgehend ungeklärt.
openaire   +3 more sources

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +2 more sources

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes [PDF]

, 2013
The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of ...
A Faivre-Bauman, A Rathinavelu, AB Abou-Samra, Abir Mukherjee, AF Gilkes, AH Tashjian Jr, AM Hamad, Andrew J. Lessey, Andrew Sunters, AR Yoder, Bigboy Simbi, CA McArdle, CA McArdle, CA McArdle, Caroline P. Wheeler-Jones, Craig A. McArdle, D Fan, D Müller, DJ Hartt, DM Dickey, FN Zeytin, G Rousseau, Gary F. Baxter, GY Koh, H Chusho, H Hao, I Kishimoto, Iain R. Thompson, Imelda M. McGonnell, IR Thompson, IR Thompson, J Horvath, KN Pandey, KN Pandey, Lorna Smith, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, MA Vieira, Mark S. Roberson, MB Henesy, MJ Lopez, N Tamura, PM Hinkle, RC Fowkes, RC Fowkes, RC Fowkes, RC Fowkes, Robert C. Fowkes, S Inagaki, S Suga, SA Bayol, Samantha M. Mirczuk, SE Abbey, SE Abbey-Hosch, SE Abbey-Hosch, SW John, T Sudoh, Victoria J. Lipscomb, Y Komatsu, Y Shimekake   +65 more
core   +3 more sources

SHP2 Nuclear/Cytoplasmic Trafficking in Granulosa Cells Is Essential for Oocyte Meiotic Resumption and Maturation

Frontiers in Cell and Developmental Biology, 2021
Src-homology-2-containing phosphotyrosine phosphatase (SHP2), a classic cytoplasmic protein and a major regulator of receptor tyrosine kinases and G protein-coupled receptors, plays a significant role in preimplantation embryo development. In this study,
Muhammad Idrees, Vikas Kumar, Myeong-Don Joo, Niaz Ali, Keun-Woo Lee, Il-Keun Kong, Il-Keun Kong   +6 more
doaj   +1 more source

New mechanism underlying IL-31-induced atopic dermatitis [PDF]

, 2018
LBK
Buddenkotte, Joerg, Buhl, Timo, Feld, Micha, Fischer, Michael, Ghetti, Andre, Meng, Jianghui, Miller, Paul, Moriyama, Masaki, Reeh, Peter W., Shan, Chunxu, Steinhoff, Martin, Szöllősi, Attila Gábor, Wang, Jiafu, Zhang, Jingming   +13 more
core   +1 more source