Results 51 to 60 of about 5,736 (234)

Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Carotid artery intima/media thickness (IMT) is a hallmark trait associated with future cardiovascular events. The goal of this study was to map new genes that regulate carotid IMT by genome‐wide association.
Vyacheslav A. Korshunov, Elaine M. Smolock, Mary E. Wines‐Samuelson, Abrar Faiyaz, Deanne M. Mickelsen, Breandan Quinn, Calvin Pan, George J. Dugbartey, Chen Yan, Marvin M. Doyley, Aldons J. Lusis, Bradford C. Berk   +11 more
doaj   +1 more source

An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene. [PDF]

PLoS ONE, 2012
We describe a three-generation family with tall stature, scoliosis and macrodactyly of the great toes and a heterozygous p.Val883Met mutation in Npr2, the gene that encodes the CNP receptor NPR2 (natriuretic peptide receptor 2). When expressed in HEK293A
Kohji Miura, Noriyuki Namba, Makoto Fujiwara, Yasuhisa Ohata, Hidekazu Ishida, Taichi Kitaoka, Takuo Kubota, Haruhiko Hirai, Chikahisa Higuchi, Noriyuki Tsumaki, Hideki Yoshikawa, Norio Sakai, Toshimi Michigami, Keiichi Ozono   +13 more
doaj   +1 more source

The receptor guanylyl cyclase Npr2 regulates the bifurcation of cranial sensory axons

, 2013
Die axonale Verzweigung ist ein wichtiger Mechanismus, um die komplexen Verschaltungen des Nervensystems zu bilden. Je nach ihrer Funktion können sich Axone weitläufig verzweigen, um die Informationen an ihre verschiedenen Ziele zu senden und ein einzigartiges Muster der Verschaltung zu etablieren. Allerdings sind die Signalmechanismen, die die axonale
Gohar Ter‐Avetisyan
openalex   +2 more sources

Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth

JCI Insight, 2021
Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase both result in decreased production of cyclic GMP in chondrocytes and severe short stature ...
Leia C. Shuhaibar, Nabil Kaci, Jeremy R. Egbert, Thibault Horville, Léa Loisay, Giulia Vigone, Tracy F. Uliasz, Emilie Dambroise, Mark R. Swingle, Richard E. Honkanen, Martin Biosse Duplan, Laurinda A. Jaffe, Laurence Legeai-Mallet   +12 more
doaj   +1 more source

NPR2 is involved in FSH-mediated mouse oocyte meiotic resumption [PDF]

Journal of Ovarian Research, 2016
Previous studies have reported that follicle-stimulating hormone (FSH) is often added to culture media to induce oocyte meiotic resumption and maturation and to improve subsequent embryonic development during in vitro maturation (IVM). However, the underlying mechanisms remain unclear.Cumulus-oocyte complexes (COCs) were collected from ovaries 46-48 h ...
Yang, Lei, Wei, Qiang, Li, Wei, Xi, Qihui, Zhao, Xiaoe, Ma, Baohua   +5 more
openaire   +2 more sources

Heterozygous Mutations in Natriuretic Peptide Receptor-B ( NPR2 ) Are Associated with Short Stature [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2006
C-type natriuretic peptide (CNP) is an important regulator of skeletal growth. Loss-of-function mutations affecting the CNP receptor natriuretic peptide receptor-B (gene NPR2) cause the autosomal recessive skeletal dysplasia, acromesomelic dysplasia, Maroteaux type (AMDM).
Robert C. Olney, Hülya Bükülmez, Cynthia F. Bartels, Timothy C. R. Prickett, Eric A. Espiner, Lincoln R. Potter, Matthew L. Warman   +6 more
openalex   +3 more sources

The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord [PDF]

The Journal of Cell Biology, 2007
Sensory axonal projections into the spinal cord display a highly stereotyped pattern of T- or Y-shaped axon bifurcation at the dorsal root entry zone (DREZ). Here, we provide evidence that embryonic mice with an inactive receptor guanylyl cyclase Npr2 or deficient for cyclic guanosine monophosphate–dependent protein kinase I (cGKI) lack the bifurcation
Hannes Schmidt, Agne Stonkute, René Jüttner, Susanne Schäffer, Jens Buttgereit, Robert Feil, Franz Hofmann, Fritz G. Rathjen   +7 more
openalex   +4 more sources

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +3 more sources

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes [PDF]

, 2013
The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of ...
A Faivre-Bauman, A Rathinavelu, AB Abou-Samra, Abir Mukherjee, AF Gilkes, AH Tashjian Jr, AM Hamad, Andrew J. Lessey, Andrew Sunters, AR Yoder, Bigboy Simbi, CA McArdle, CA McArdle, CA McArdle, Caroline P. Wheeler-Jones, Craig A. McArdle, D Fan, D Müller, DJ Hartt, DM Dickey, FN Zeytin, G Rousseau, Gary F. Baxter, GY Koh, H Chusho, H Hao, I Kishimoto, Iain R. Thompson, Imelda M. McGonnell, IR Thompson, IR Thompson, J Horvath, KN Pandey, KN Pandey, Lorna Smith, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, MA Vieira, Mark S. Roberson, MB Henesy, MJ Lopez, N Tamura, PM Hinkle, RC Fowkes, RC Fowkes, RC Fowkes, RC Fowkes, Robert C. Fowkes, S Inagaki, S Suga, SA Bayol, Samantha M. Mirczuk, SE Abbey, SE Abbey-Hosch, SE Abbey-Hosch, SW John, T Sudoh, Victoria J. Lipscomb, Y Komatsu, Y Shimekake   +65 more
core   +4 more sources

SHP2 Nuclear/Cytoplasmic Trafficking in Granulosa Cells Is Essential for Oocyte Meiotic Resumption and Maturation

Frontiers in Cell and Developmental Biology, 2021
Src-homology-2-containing phosphotyrosine phosphatase (SHP2), a classic cytoplasmic protein and a major regulator of receptor tyrosine kinases and G protein-coupled receptors, plays a significant role in preimplantation embryo development. In this study,
Muhammad Idrees, Vikas Kumar, Myeong-Don Joo, Niaz Ali, Keun-Woo Lee, Il-Keun Kong, Il-Keun Kong   +6 more
doaj   +1 more source