Results 71 to 80 of about 4,503 (200)

Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes. [PDF]

, 2017
The natriuretic peptides, Atrial-, B-type and C-type natriuretric peptides (ANP, BNP, CNP), are regulators of many endocrine tissues and exert their effects predominantly through the activation of their specific guanylyl cyclase receptors (GC-A and GC-B)
A Faivre-Bauman, AH Tashjian Jr, B Grandclément, CA McArdle, Caroline P. Wheeler-Jones, Charlotte Lawson, CJ Caunt, Craig A. McArdle, D Guo, DJ Hartt, DL Garbers, G Chen, Gary F. Baxter, H Chusho, H Hagiwara, H Kaneki, H Rangaswami, HR De Jonge, Iain R. Thompson, Imelda M. McGonnell, IR Thompson, IR Thompson, IR Thompson, JB Sun, JM Mulvaney, JR Hirsch, K Arora, Kim C. Jonas, LR Potter, LR Potter, LR Potter, M Silberbach, M Zenitani, Mark S. Roberson, MB Anand-Srivastava, MH Cobb, MM McKay, N Tamura, N Tamura, P Krejci, PP Roux, R Potthast, RA Rose, RC Fowkes, RC Fowkes, RC Fowkes, Robert C. Fowkes, S Dhayade, S Sciarretta, SE Abbey, SE Abbey-Hosch, Stijn J. Niessen, T Miyazawa, Timothy Melrose, Victoria J. Lipscomb, W Zhang, WR Gower Jr, Y Komatsu, Y Shimekake, Z Naor   +59 more
core   +6 more sources

From Heteroaromatic acids and Imines to Azaspirocycles : Stereoselective Synthesis and 3D Shape Analysis [PDF]

, 2016
Heteroaromatic carboxylic acids have been directly coupled with imines using T3P and NEt(i-Pr)2 to form azaspirocycles via intermediate N-acyliminium ions.
Bailey, Blicke, Bonjoch, Böhme, Carreira, Chen, Coulthard, Dhankher, Firth, Gao, Heffernan, Hung, Jackson, Jackson, James, James, James, Jensen, Khorana, Kitsiou, Klein, Li, Liedtke, Lovering, Lüthy, Marti, Maryanoff, Menciu, Meyer, Morley, Mérour, Okano, Overman, Peshkov, Piazzi, Roche, Sauer, Shabalina, Shanker, Shao, Shi, Siau, Sippy, Stöckigt, Taylor, Trzupek, Unsworth, Unsworth, Unsworth, Unsworth, Vitaku, Wagnières, Walton, Wang, Woodward, Wu, Wu, Wu, Zheng, Zheng, Zhou, Zhu, Zhuo, Zhuo, Zhuo, Zhuo   +65 more
core   +2 more sources

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

C-Type Natriuretic Peptide/Natriuretic Peptide Receptor 2 Is Involved in Cell Proliferation and Testosterone Production in Mouse Leydig Cells

The World Journal of Men's Health, 2019
Purpose: This study investigated the role of natriuretic peptide receptor 2 (NPR2) on cell proliferation and testosterone secre-tion in mouse Leydig cells.Materials and Methods: Mouse testis of different postnatal stages was isolated to detect the ...
Lei Yang, Lanjie Lei, Qihan Zhao, Ying Gong, Gaopeng Guan, Shaoxin Huang   +5 more
doaj   +1 more source

Tall Stature and Scoliosis Associated With a Novel Homozygous Loss‐of‐Function Missense Variant in NPR3

American Journal of Medical Genetics Part A, Volume 197, Issue 8, August 2025.
ABSTRACT NPR3‐related tall stature is characterized by tall stature, elongated big toes, and additional epiphyses in hand and foot bones. The condition is caused by biallelic loss‐of‐function variants affecting natriuretic peptide receptor 3 (NPR3). Five individuals from four different families have been reported.
Pierre Moffatt, Chantal Janelle, Valancy Miranda, Ghalib Bardai, Frank Rauch   +4 more
wiley   +1 more source

Signaling mechanisms and their regulation during in vivo or in vitro maturation of mammalian oocytes

Reproductive Biology and Endocrinology, 2022
In vitro fertilization (IVF) is currently one of the most effective methods of infertility treatment. An alternative to commonly used ovarian hyperstimulation can become extracorporeal maturation of oocytes (in vitro maturation; IVM).
Patrycja Strączyńska, Krzysztof Papis, Emilia Morawiec, Michał Czerwiński, Zdzisław Gajewski, Anita Olejek, Anna Bednarska-Czerwińska   +6 more
doaj   +1 more source

VARIABILITY OF THE GENES OF NATRIURETIC PEPTIDES AND ANTIOXIDANT PROTECTION IN PATIENTS WITH MYOCARDIAL INFARCTION

Байкальский медицинский журнал, 2023
Introduction. Cardiovascular diseases (CVD) continue to be the subject of scientific research in relation to molecular genetic predictors of their development.
O. N. Khryachkova, Maria V. Khutornaya, A. V. Sinitskaya, Alyona O Poddubnyak, A V Ponasenko   +4 more
doaj   +1 more source

Whole exome sequencing to identify genetic causes of short stature [PDF]

, 2014
BACKGROUND/AIMS: Short stature is a common reason for presentation to pediatric endocrinology clinics. However, for most patients, no cause for the short stature can be identified.
Dauber, Andrew, Guo, Michael H., Hirschhorn, Joel N., Miller, Timothy C., Moon, Jennifer E., Shen, Yiping, Walvoord, Emily C.   +6 more
core   +1 more source

Identification and Functional Characterization of Two Novel NPR2 Mutations in Japanese Patients With Short Stature [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2014
C-type natriuretic peptide-natriuretic peptide receptor B (NPR-B) signaling is critical for endochondral ossification, which is responsible for longitudinal growth in limbs and vertebrae. Biallelic NPR2 mutations cause acromesomelic dysplasia, type Maroteaux, which is bone dysplasia characterized by severe short stature and short limbs.
Naoko Amano, Tokuo Mukai, Yoshiya Ito, Satoshi Narumi, Toshiaki Tanaka, Susumu Yokoya, Tsutomu Ogata, Tomonobu Hasegawa   +7 more
openalex   +4 more sources

Transcriptional Profiling of SSEA‐1+ Endometrial Epithelial Progenitor Cells Highlights Their Role in Endometrial Regeneration, Remodeling, and Homeostasis

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Sampling, isolation, cell sorting and microarray analysis of SSEA‐1+ endometrial epithelial progenitor cells. Gene expression data was analysed using computational pathway analysis methods and internally validated using real‐time quantitative PCR and externally validated using dual‐label immunofluorescence and endometrial epithelial organoid models ...
Hannan Al‐Lamee, Jamie Soul, Daniel Green, Josephine Drury, Christopher J. Hill, Olga Vasieva, Anthony Valentijn, Alison Maclean, Andrew Drakeley, Nicola Tempest, Dharani K. Hapangama   +10 more
wiley   +1 more source