Results 81 to 90 of about 5,736 (234)

Genetic Polymorphisms of the Natriuretic Peptide System in the Pathogenesis of Cardiovascular Disease: What Lies on the Horizon? [PDF]

, 2009
BACKGROUND: The natriuretic peptide hormone family includes various proteins characterized by similar chemical structure and shared biological functions, with important effects on the cardiovascular system.
Andreassi, Maria Grazia, Vassalle, Cristina   +1 more
core   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Effect of C-Type Natriuretic Peptide on Maturation and Developmental Competence of Goat Oocytes Matured In Vitro. [PDF]

PLoS ONE, 2015
The developmental competence of oocytes during in vitro maturation (IVM) is compromised due to asynchronous nuclear and cytoplasmic maturation. To improve IVM efficiency, a pre-maturation culture or two-step maturation strategy has been established ...
Junhong Zhang, Qiang Wei, Jiao Cai, Xiaoe Zhao, Baohua Ma   +4 more
doaj   +1 more source

Asthma in Patients With Confirmed Pulmonary Sarcoidosis

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Pulmonary sarcoidosis and asthma can present identical symptoms, making clinical evaluation difficult if the two diseases overlap. Diagnostic challenges often lead to either overdiagnosis of asthma in patients with confirmed sarcoidosis or withholding appropriate asthma treatment.
Agata Anna Lewandowska, Dorota Waśniowska, Małgorzata Kołodziej, Helena Mirus-Arabik, Aleksandra Gaczkowska, Ola Duszyńska, Krzysztof Bułat, Michał Graczyk, Cezary Rybacki, Lipi Buch   +9 more
wiley   +1 more source

The Absence of Sensory Axon Bifurcation Affects Nociception and Termination Fields of Afferents in the Spinal Cord

Frontiers in Molecular Neuroscience, 2018
A cGMP signaling cascade composed of C-type natriuretic peptide, the guanylyl cyclase receptor Npr2 and cGMP-dependent protein kinase I (cGKI) controls the bifurcation of sensory axons upon entering the spinal cord during embryonic development.
Philip Tröster, Julia Haseleu, Jonas Petersen, Jonas Petersen, Oliver Drees, Achim Schmidtko, Achim Schmidtko, Frederick Schwaller, Gary R. Lewin, Gohar Ter-Avetisyan, York Winter, Stefanie Peters, Susanne Feil, Robert Feil, Fritz G. Rathjen, Hannes Schmidt   +15 more
doaj   +1 more source

Fibroblast growth factor signaling in skeletal development and disease [PDF]

, 2015
Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate skeletal development. FGF signaling regulates development of the limb bud and formation of the mesenchymal condensation and has key roles in regulating ...
Marie, Pierre J, Ornitz, David M
core   +2 more sources

Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations

MedComm, Volume 6, Issue 12, December 2025.
Along with organismal aging or pathogenic processes especially tumor, multiple immune cell types exhibit those well‐established hallmarks of cellular senescent phenotype, mainly characterized by irreversible cell cycle arrest, metabolic disorder, and over production of SASP.
Ninghan Gong, Xiting Pan, Yusi Deng, Jiajia Che, Junhao Bao, Mengqi Wang, Chuan Xu, Xiaowei Liu, Ying Shi   +8 more
wiley   +1 more source

C-Type Natriuretic Peptide/Natriuretic Peptide Receptor 2 Is Involved in Cell Proliferation and Testosterone Production in Mouse Leydig Cells

The World Journal of Men's Health, 2019
Purpose: This study investigated the role of natriuretic peptide receptor 2 (NPR2) on cell proliferation and testosterone secre-tion in mouse Leydig cells.Materials and Methods: Mouse testis of different postnatal stages was isolated to detect the ...
Lei Yang, Lanjie Lei, Qihan Zhao, Ying Gong, Gaopeng Guan, Shaoxin Huang   +5 more
doaj   +1 more source

Furin‐Mediated Cleavage of Zona Pellucida Proteins Is Essential for Oocyte Development

MedComm, Volume 6, Issue 12, December 2025.
The furin cleavage site mutation leads to a failure in transmembrane transport process of non‐modified ZP2 protein. This unsuccessful ZP2 secretion might result in the decreased expression of exocytosis complex SNAREs, which further induces oocyte apoptosis via p53 pathway and PI3K signaling.
Tiechao Ruan, Xiang Wang, Xueguang Zhang, Yan Wang, Chuan Jiang, Sixian Wu, Yunchuan Tian, Xinyao Tang, Jun Ma, Shikun Zhao, Liangchai Zhuo, Mohan Liu, Siyu Dai, Zhenbo Wang, Wenming Xu, Ying Shen   +15 more
wiley   +1 more source

Fatigue Life Prediction Under Multiaxial Loading Using Machine Learning and Dependency‐Aware Sensitivity Analysis

International Journal of Mechanical System Dynamics, Volume 5, Issue 4, Page 736-761, December 2025.
ABSTRACT Accurate prediction of fatigue life under multiaxial loading conditions remains challenging due to complex stress–strain interactions. In this study, we integrate machine‐learning (ML) regression with variance‐based sensitivity analysis (SA) to predict multiaxial fatigue life in CuZn37 brass and to identify the dominant mechanical factors ...
Tran C. H. Nguyen, Xiaoying Zhuang, Anh Tuan Le, Van Hai Luong, N. Vu‐Bac   +4 more
wiley   +1 more source