Results 241 to 250 of about 117,023 (322)

Metal‐Coordination Specificity and Structural Dynamics of C. elegans Metallothionein I: Insights From 3D Modeling and MD Simulations

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Metallothioneins (MTLs) are small, cysteine‐rich proteins known for their ability to bind metal ions and exhibit flexible, disordered structures. The structural and functional characteristics of metallothionein I (MTL‐1) from Caenorhabditis elegans were investigated, focusing on its behavior in both metal free (MTL‐1 Apo) and metal‐bond states
Nilvea Ramalho de Oliveira   +4 more
wiley   +1 more source

In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini   +5 more
wiley   +1 more source

Human Citrate Synthase Post‐Translational Modification Mimics and Molecular Dynamic Simulations Demonstrate Attenuation of Acetyl‐CoA/CoA Binding

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human citrate synthase (hCS) is a mitochondrial enzyme that catalyzes the aldol condensation of acetyl coenzyme A (AcCoA) to oxaloacetate to form citrate in the TCA cycle. CS activity is important for aerobic exercise performance and basic metabolic function as a housekeeping enzyme.
Noah Shackelford   +3 more
wiley   +1 more source

Just-in-case medication use by ambulance paramedics responding to end-of-life care in the community: protocol for a multi-method study (RELIEF). [PDF]

open access: yesBr Paramed J
Moore C   +12 more
europepmc   +1 more source

Computational Characterization of the Role of LEM2/LaminA Interactions on the Stability of BAF‐Dimer Using Molecular Simulations

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The effect of the presence of the BAF‐binding LEM‐domain and LaminA Ig‐fold on the stability of the BAF dimer was studied qualitatively using non‐equilibrium pull simulations and quantitatively through the calculation of the potential of mean force profile along BAF–BAF separation distance.
Aswin Vinod Muthachikavil   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy