Results 71 to 80 of about 119,560 (316)

Shared Responsibilities for Nuclear Disarmament: A Global Debate [PDF]

, 2010
Presents Sagan's 2009 paper calling for rethinking the balance of responsibilities and the relationship between articles in the Nuclear Non-Proliferation Treaty with seven response papers by international scholars about how to pursue nuclear ...
Achilles Zaluar, Harald Muller, James M. Acton, Jayantha Dhanapala, Mohamed I. Shaker, Mustafa Kibaroglu, Scott D. Sagan, Yukio Satoh   +7 more
core  

Black hole evaporation in a heat bath as a nonequilibrium process and its final fate

, 2007
When a black hole evaporates, there arises a net energy flow from black hole into its outside environment (heat bath). The existence of energy flow means that the thermodynamic state of the whole system, which consists of the black hole and the heat bath,
Binney J, Carr B J, Hawking S W, Hawking S W, Hiromi Saida, Hossenfelder S, Kippenhahn R, Landau L D, Saida H, Saida H, Saida H Harada T Maeda H, Stephens C R, Strominger A, Tolman R C, Zeldovich Y B   +14 more
core   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma

Cancer Medicine, 2018
This study aimed at evaluating the diagnostic and prognostic role of neopterin (Npt) concentration in the cerebrospinal fluid (CSF) of patients with primary central nervous system lymphoma (PCNSL). Ninety‐nine patients were enrolled in this retrospective
Mingying Geng, He Xiao, Jiaqi Liu, Yang Song, Ping Fu, Xing Cheng, Jinwei Zhang, Ge Wang   +7 more
doaj   +1 more source

Using Normalization Process Theory in feasibility studies and process evaluations of complex healthcare interventions: a systematic review

Implementation Science, 2018
Background Normalization Process Theory (NPT) identifies, characterises and explains key mechanisms that promote and inhibit the implementation, embedding and integration of new health techniques, technologies and other complex interventions.
Carl R. May, Amanda Cummings, Melissa Girling, Mike Bracher, Frances S. Mair, Christine M. May, Elizabeth Murray, Michelle Myall, Tim Rapley, Tracy Finch   +9 more
doaj   +1 more source

Severe, Non-apneic Respiratory Dysfunction and Hypoxia following Generalized Convulsive Seizures. [PDF]

Ann Neurol
Objective Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently without characterizing the adequacy of non‐apneic ventilation or identifying other dysfunctional breathing patterns.
Pysick HE, Sainju RK, Nair R, Dragon DN, Bravo E, Vilella L, Li X, Lhatoo SD, Richerson GB, Gehlbach BK.   +9 more
europepmc   +2 more sources

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Multiplicity Fluctuations in Limited Segments of Momentum Space in Statistical Models

, 2007
Multiplicity fluctuations in limited segments of momentum space are calculated for a classical pion gas within the statistical model. Results for the grand canonical, canonical, and micro-canonical ensemble are obtained, compared and discussed.
B. Lungwitz, M. Stephanov, Michael Hauer, S. Jeon   +3 more
core   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Clinical usefulness of serum neopterin in children with juvenile idiopathic arthritis

Pteridines, 2015
The aim of this study was to analyze the usefulness of the serum concentration of neopterin (NPT) as a marker of juvenile idiopathic arthritis (JIA). The study included 67 children with JIA (36 girls and 31 boys), aged between 3.8 and 17.9 years (mean 13.
Plata-Nazar Katarzyna, Szumera Małgorzata, Łuczak Grażyna, Liberek Anna, Sznurkowska Katarzyna, Szlagatys-Sidorkiewicz Agnieszka, Lange Magdalena, Kamińska Barbara   +7 more
doaj   +1 more source