Results 51 to 60 of about 855,290 (279)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Improvements in DCCP congestion control for satellite links [PDF]
, 2008 We propose modifications in the TCP-Friendly Rate Control (TFRC) congestion control mechanism from the Datagram Congestion Control Protocol (DCCP) intended for use with real-time traffic, which are aimed at improving its performance for long delay ...
Boreli, Roksana +3 more
core +2 more sources
Transplantation DirectBackground. Posttransplant lymphoproliferative disease (PTLD) is increased in kidney transplant recipients who are Epstein-Barr virus (EBV) nonimmune (R–), particularly if the donor has prior EBV immunity (D+). PTLD is associated with very high mortality.
Bryce A. Kiberd, MD +1 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Implementation and performance analysis of a QoS-aware TFRC mechanism [PDF]
, 2006 This paper deals with the improvement of transport protocol behaviour over the DiffServ Assured Forwarding (AF)class. The Assured Service (AS) provides a minimum throughput guarantee that classical congestion control mechanisms, like window-based in TCP ...
Dairaine, Laurent +5 more
core +3 more sources
Effect of hydro-alcoholic extract of Nigella sativa on cisplatin-induced memory impairment and brain oxidative stress status in male rats [PDF]
Avicenna Journal of PhytomedicineObjective: Studies have shown the complications of chemotherapy on learning and memory. Empirical evidence suggests that Nigella sativa (NS) has neuroprotective activities. Therefore, the aim of our study was to investigate the effects of NS on cisplatin-
Yasin Mahmoud Janloo +7 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Performance of active multicast congestion control [PDF]
, 2000 This paper aims to provide insight into the behavior of congestion control mechanisms for reliable multicast protocols. A multicast congestion control based on active networks has been proposed and simulated using ns-2 over a network topology obtained ...
Azcorra, Arturo +2 more
core +3 more sources
Network Performance Analysis Based on Network Simulator NS-2.
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2018 NS-2 is a tool to simulate networks and events that occur per packet sequentially based on time and are widely used in the research field. NS-2 comes with NAM (Network Animator) that produces a visual representation it also supports several ...
Maan Y. Anad Alsaleem +2 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source