Results 251 to 260 of about 245,924 (389)

Incorporating Multiple Imputation Into Tanezumab Dose–Response Modeling of WOMAC Pain CFB Across Six Randomized Placebo‐Controlled Phase 3 Trials

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Multiple imputation is increasingly being used to deal with missing data in clinical trials. It is a simulation approach leading to multiple analyses of a pre‐defined number of datasets. For a pre‐defined statistical model, this is relatively straightforward, but for model development as typically conducted in Pharmacometrics, it is unclear ...
Martin Boucher, Scott Marshall, Puneet Gaitonde   +2 more
wiley   +1 more source

Nonsteroidal anti-inflammatory drug use is associated with improved activities of daily living and rehabilitation in older adult patients following a fracture: a retrospective cohort study. [PDF]

J Pharm Health Care Sci
Kose E, Endo H, Hori H, Hosono S, Kawamura C, Kodama Y, Yamazaki T, Kimura T.   +7 more
europepmc   +1 more source

Par-4, a pro-apoptotic gene, is regulated by NSAIDs in human colon carcinoma cells

, 2000
Zhonghua Zhang, Raymond N. DuBois
openalex   +1 more source

The effectiveness and value of suzetrigine for moderate to severe acute pain: A summary from the Institute for Clinical and Economic Review's Midwest Comparative Effectiveness Public Advisory Council. [PDF]

J Manag Care Spec Pharm
Nikitin D, Rind DM, McQueen B, Raymond F, Sanchez S, DiStefano MJ, Zemplenyi A, Lee W, Ollendorf D.   +8 more
europepmc   +1 more source

Bimodal Dissolving Microneedles with Nanoparticle Coating and Encapsulation for Extended Dual‐Drug Delivery

Small, EarlyView.
A novel bimodal coated‐dissolving microneedle system is developed for extended transdermal delivery of diclofenac and dexamethasone nanoparticles. The formulation enables high drug loading, efficient skin penetration, and sustained release over 72 h, offering a minimally invasive, self‐administered therapy to improve osteoarthritis treatment by ...
Mingshan Li, Akmal H.B. Sabri, Nuoya Qin, Ke Peng, Marco Abbate, Alejandro J. Paredes, Helen O McCarthy, Lalitkumar K. Vora, Ryan F. Donnelly   +8 more
wiley   +1 more source

Pharmacovigilance analysis of small bowel bleeding associated with NSAIDs. [PDF]

Ther Adv Drug Saf
Deng YH, Jiang M, Chen Y, Chen HB.
europepmc   +1 more source

Celecoxib is associated with a lower incidence of serious GI toxicity relative to nonsteroidal anti-inflammatory drugs (NSAIDs)

, 2000
JL Goldstein
openalex   +1 more source

Curcumin ameliorates hyperuricemia and gout‐induced damage via modulating the ROS‐dependent NEK7‐NLRP3 inflammasome activation

Smart Molecules, EarlyView.
Curcumin inhibits the ROS/NEK7‐NLRP3 inflammasome pathway by reducing reactive oxygen species (ROS) levels and disrupting the association of the NEK7‐NLRP3 complex. These combined effects of curcumin result in suppression of the GSDMD‐N pyroptotic pore formation and subsequent reduction of IL‐1β release.
Zhengtian Zhao, Xiaowei Tong, Jing Sun, Jiaqi Lu, Guangyu Zhang, Qing Wang, Li Yang   +6 more
wiley   +1 more source

Adverse Reactions With VEGF Inhibitors in Combination With NSAIDs: Disproportionality Analysis Using JADRE and FAERS. [PDF]

In Vivo
Saito K, Nihei S, Asaka J, Kudo K.
europepmc   +1 more source

1012 Nimesulide as an alternative in patients with allergic reactions to NSAID

, 2000
J. Mori
openalex   +1 more source