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NSAID induced gastrointestinal damage and designing GI-sparing NSAIDs
Expert Review of Clinical Pharmacology, 2018NSAIDs are widely used to treat pain and rheumatic conditions, but they induce adverse events in different body systems, although the major, most frequent events occur in the upper and lower gastrointestinal (GI) tracts.
G. García-Rayado +2 more
semanticscholar +1 more source
European Journal of Gastroenterology & Hepatology, 1999
There have been many studies documenting the deleterious effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the gastrointestinal tract, and it is widely accepted that these agents cause mucosal damage in the stomach, duodenum, jejunum, ileum and colon.
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There have been many studies documenting the deleterious effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the gastrointestinal tract, and it is widely accepted that these agents cause mucosal damage in the stomach, duodenum, jejunum, ileum and colon.
openaire +3 more sources
BMJ, 2016
NSAIDs pose a clear risk to some patients and tighter regulation is justified Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs and are mainly used to alleviate pain and inflammation. NSAIDs were first introduced over a century ago and most of the commonly used NSAIDs were registered in an era with few requirements ...
Gunnar Gislason +3 more
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NSAIDs pose a clear risk to some patients and tighter regulation is justified Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs and are mainly used to alleviate pain and inflammation. NSAIDs were first introduced over a century ago and most of the commonly used NSAIDs were registered in an era with few requirements ...
Gunnar Gislason +3 more
openaire +4 more sources
Cellular and Molecular Life Sciences, 2008
Regular use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with decreased incidence of cancer of the colon and other gastrointestinal organs. The chemopreventive properties of NSAIDs are due to their ability to induce apoptosis.
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Regular use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with decreased incidence of cancer of the colon and other gastrointestinal organs. The chemopreventive properties of NSAIDs are due to their ability to induce apoptosis.
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Southern Medical Journal, 1987
The use of NSAIDs masked the diagnosis of gout in nine patients with the chronic polyarticular form of the disease. The escape from detection of chronic polyarticular gout resulted in a needless dependence on NSAIDs, failure to correct the metabolic problem, and in some cases progression of joint destruction.
Scopelitis, E, McGrath, H
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The use of NSAIDs masked the diagnosis of gout in nine patients with the chronic polyarticular form of the disease. The escape from detection of chronic polyarticular gout resulted in a needless dependence on NSAIDs, failure to correct the metabolic problem, and in some cases progression of joint destruction.
Scopelitis, E, McGrath, H
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Hospital Practice, 1991
The ability of aspirin and related drugs to inhibit prostaglandin biosynthesis accounts for many effects of NSAIDs but does not completely explain their efficacy against inflammation. An additional mechanism may be disruption of the intracellular signal pathways responsible for activation of inflammatory cells--notably, neutrophils.
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The ability of aspirin and related drugs to inhibit prostaglandin biosynthesis accounts for many effects of NSAIDs but does not completely explain their efficacy against inflammation. An additional mechanism may be disruption of the intracellular signal pathways responsible for activation of inflammatory cells--notably, neutrophils.
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Current Opinion in Rheumatology, 2013
Published data raise concerns about the use of nonselective NSAIDs and selective cyclo-oxygenase (COX)-2 inhibitors as anti-inflammatory or analgesic drugs in patients after a recent fracture or who are undergoing (uncemented) arthroplasty or osteotomy.
Joost J. A. de Jong +3 more
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Published data raise concerns about the use of nonselective NSAIDs and selective cyclo-oxygenase (COX)-2 inhibitors as anti-inflammatory or analgesic drugs in patients after a recent fracture or who are undergoing (uncemented) arthroplasty or osteotomy.
Joost J. A. de Jong +3 more
openaire +4 more sources
Journal of the American Chemical Society, 2018
Many therapeutics elicit cell-type specific polypharmacology that is executed by a network of molecular recognition events between a small molecule and the whole proteome.
Jinxu Gao +3 more
semanticscholar +1 more source
Many therapeutics elicit cell-type specific polypharmacology that is executed by a network of molecular recognition events between a small molecule and the whole proteome.
Jinxu Gao +3 more
semanticscholar +1 more source
NSAIDs and cardiovascular disease
Heart, 2007Non-steroidal anti-inflammatory drugs (NSAIDs) are a chemically heterogeneous group of agents to treat symptoms of acute pain and chronic inflammatory and degenerative joint diseases, such as rheumatoid arthritis (RA) and osteoarthritis (OA).1 They act mostly through the inhibition of cyclooxygenase-2 (COX-2)-dependent prostanoids.
PATRIGNANI, Paola +2 more
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NSAIDS AND THE MICROCIRCULATION OF THE STOMACH
Gastroenterology Clinics of North America, 1996In this article, the effect of NSAIDs on the gastric mucosal microcirculation was reported. Although the precise mechanism of NSAID-induced ulcerogenesis is still unknown, most NSAIDs have been shown to impair gastric mucosal microcirculation and cause gastric mucosal damage.
Nobuhiro Sato +3 more
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