Systematic study of constitutive cyclo-oxygenase-2 expression: role of NFκB and NFAT transcriptional pathways [PDF]
, 2015 Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs).
Ahmetaj-Shala, B +11 more
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Journal of Pain Research, 2021 Stefania Di Gangi,1 Christophe Bagnoud,2 Giuseppe Pichierri,1 Thomas Rosemann,1 Andreas Plate1 1Institute of Primary Care, University and University Hospital Zurich, Zürich, Switzerland; 2Groupe Mutuel, Martigny, SwitzerlandCorrespondence: Stefania Di ...
Di Gangi S +4 more
doaj
Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Regarding Lemon verbena gastroprotective effects, we investigated the protective effects of Lemon verbena extracts on reducing gastric ulcer induced by indomethacin.Materials and Methods: Rats received aqueous and ethanolic extracts of ...
Habibeh Mashayekhi-sardoo +4 more
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Multicentre observational cohort study of NSAIDs as risk factors for postoperative adverse events in gastrointestinal surgery [PDF]
, 2014 Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended as postoperative analgesia by the Enhanced Recovery After Surgery Society. Recent studies have raised concerns that NSAID administration following colorectal anastomosis may be ...
Bhangu, A +6 more
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Severe osteoarticular involvement in isotretinoin-triggered acne fulminans: two cases successfully treated with anakinra. [PDF]
, 2017 Acne fulminans (AF) is a severe form of inflammatory and ulcerated acne associated with fever, malaise, joint swellings and polyarthralgia.1 Osteoarticular lesions are often described and can be radiologically indistinguishable from those observed in
Barbareschi +9 more
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ClinicoEconomics and Outcomes Research, 2021 Viktor V Chirikov,1 Chris Walker,2 Jennifer M Stephens,1 Patricia Schepman,3 Richard Chambers,4 Mahmoud Bakir,5 Gregory W Poorman,1 Seema Haider,6 Mohammed Farghaly7 1OPEN Health, Bethesda, MD, USA; 2Global Medical Affairs, Viatris, Tadworth, UK; 3Global
Chirikov VV +8 more
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Future directions for the management of pain in osteoarthritis. [PDF]
, 2014 Osteoarthritis (OA) is the predominant form of arthritis worldwide, resulting in a high degree of functional impairment and reduced quality of life owing to chronic pain. To date, there are no treatments that are known to modify disease progression of OA
Aigner T +23 more
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Developing a complex intervention to improve prescribing safety in primary care:mixed methods feasibility and optimisation pilot study [PDF]
, 2014 Objectives (A) To measure the extent to which different candidate outcome measures identified high-risk prescribing that is potentially changeable by the data-driven quality improvement in primary care (DQIP) intervention.(B) To explore the value of ...
Dreischulte, Tobias +2 more
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Contribution of non-steroidal anti-inflammatory drugs to breast cancer treatment: In vitro and in vivo studies [PDF]
Veterinary WorldChronic inflammation plays a crucial role in carcinogenesis. High levels of serum prostaglandin E2 and tissue overexpression of cyclooxygenase-2 (COX-2) have been described in breast, urinary, colorectal, prostate, and lung cancers as being involved in ...
Tiago Ferreira +5 more
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Терапевтический архив, 2020 Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used drugs in the world, and their side effects are very high. First of all, these are NSAID gastropathy, but in the long term, 5070% of NSAIDs cause damage to the small intestine
E. N. Kareva
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