Results 11 to 20 of about 362,523 (334)

Immunotherapeutic Advances for NSCLC

Biologics: Targets and Therapy, 2021
Immunotherapy with antibodies against PD-1 or PD-L1, either alone or in combination with chemotherapy, has revolutionized treatment paradigms of non-small cell lung cancer (NSCLC) patients without oncogenic driver alterations. These agents, namely immune checkpoint inhibitors (ICIs), have also widely demonstrated a remarkable efficacy in locally ...
M Massafra, Passalacqua MI, V Gebbia, PAOLO MACRÌ, C Lazzari, V Gregorc, C Buda, G Altavilla, M Santarpia   +8 more
openalex   +6 more sources

Liquid Biopsy and NSCLC [PDF]

Lung Cancer Management, 2016
In the era of high-throughput molecular screening and personalized medicine, difficulty in determining whether cancer mutations are truly 'actionable' remains a gray zone in NSCLC. The most important prerequisite to perform such investigations is the tumor tissue retrieval via biopsy at diagnosis and after occurrence of resistance.
Trombetta, D., Sparaneo, A., Fabrizio, F. P., Muscarella, L. A.   +3 more
openaire   +2 more sources

PI3K Pathway in NSCLC [PDF]

Frontiers in Oncology, 2012
The phosphatidylinositol 3-kinases (PI3Ks) are members of a family of intracellular lipid kinases that phosphorylate the 3'-hydroxyl group of phosphatidylinositol and phosphoinositides. PI3K regulate signaling pathways for neoplasia, including cell proliferation, adhesion, survival, and motility.
Martinez-Martí, Alex, Felip, Enriqueta
openaire   +3 more sources

Synoptic reporting in lung cancers using Lung Cancer Reporting and Data System (LC-RADS): The road ahead for standardization of imaging in lung cancer staging

Cancer Research, Statistics, and Treatment, 2021
Words are the most important and sometimes the only medium of communication between a radiologist and a treating physician. The concept of structured reporting in radiology was well received in the face of growing concerns to overcome the limitations of ...
Abhishek Mahajan
doaj   +1 more source

Simple and objective prediction of survival in patients with lung cancer: staging the host systemic inflammatory response [PDF]

, 2014
Background. Prediction of survival in patients diagnosed with lung cancer remains problematical. The aim of the present study was to examine the clinical utility of an established objective marker of the systemic inflammatory response, the Glasgow ...
Brown, Louise, Devereux, Graham, Docherty, Kirsty, Grose, Derek, Jones, Richard, McElhinney, Penny, McIntosh, David, McMillan, Donald C., Milroy, Robert, Morrison, David S., Nicolson, Marianne, Selby, Colin, Sharma, Dave   +12 more
core   +4 more sources

Assessing Toripalimab in NSCLC [PDF]

Cancer Discovery, 2022
Abstract According to CHOICE-01, a phase III trial in China, the PD-1 inhibitor toripalimab plus chemotherapy improves progression-free survival in patients with untreated non–small cell lung cancer lacking actionable mutations. The findings boost combination chemo–immunotherapy, rather than chemotherapy alone, as the new standard for ...

openalex   +3 more sources

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]

, 2015
BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir, Lewis, Michael, Lu, Jie, Mortazavi, Fariborz, Pezeshkpour, Gholamhossein, Phan, Ryan, Tamanoi, Fuyuhiko, Trinidad, Kenny   +7 more
core   +2 more sources

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells [PDF]

, 2016
Cancer stem cells (CSCs) play an important role in tumor initiation, progression, therapeutic failure and tumor relapse. In this study, we evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl ...
Buglioni, Simonetta, Carradori, Simone, DE LUCA, Teresa, De Maria, Ruggero, Del Bufalo, Donatella, Desideri, Marianna, DI MARTILE, Marta, Eramo, Adriana, Gabellini, Chiara, Mai, Antonello, Milella, MICHELE STANISLAW, Rotili, Dante, Secci, Daniela, Sette, Giovanni, Trisciuoglio, Daniela   +14 more
core   +7 more sources

GPX2 and BMP4 as Significant Molecular Alterations in The Lung Adenocarcinoma Progression: Integrated Bioinformatics Analysis [PDF]

Cell Journal, 2022
Objective: Non-small cell lung adenocarcinoma (NSCLC) is the most common type of lung cancer, which is considered as the most lethal and prevalent cancer worldwide. Recently, molecular changes have been implicated to play a significant role in the cancer
Mohammad Hossein Derakhshan Nazari, Rana Askari Dastjerdi, Parnian Ghaedi Talkhouncheh, Ahmad Bereimipour, Hamidreza Mollasalehi, Amir Ali Mahshad, Ali Razi, Mohammad Hossein Nazari, Amin Ebrahimi Sadrabadi, Sara Taleahmad   +9 more
doaj   +1 more source

Salivary cytokine panel indicative of non-small cell lung cancer. [PDF]

, 2018
Objective To develop a combinatorial panel of salivary cytokines that manifests the presence of non-small cell lung cancer (NSCLC) that will eventually improve prognosis by facilitating the early diagnosis and management of this common cancer. Methods We
Koizumi, Tomonobu, Shetty, Vivek, Yamaguchi, Masaki   +2 more
core   +3 more sources