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Structure and function of rotavirus nonstructural protein NSP3
1996The genomes of viruses in the family Reoviridae consist of segmented double-stranded RNA. There are 10 to 12 segments depending on the genus. The 5' ends and the 3' ends of the RNAs present conserved motifs for each virus genus. These conserved motifs have been hypothesized to play a role in genomic segment assortment during virus morphogenesis.
Poncet, Didier, Aponte, C., Cohen, J.
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Phosphorylation of sindbis virus nsP3 in vivo and in vitro
Virology, 1990nsP3 is one of four viral nonstructural proteins required for RNA replication of Sindbis virus. In this report, post-translational modifications of nsP3 which occur in both vertebrate and mosquito cell cultures have been examined. In pulse-chase experiments, analyzed by immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis ...
Li, Guangpu +4 more
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A Method to Monitor Activity of SARS-CoV-2 Nsp3 from Cells
2022SARS-CoV-2 protease Nsp3 is a therapeutic target for developing anti-SARS-CoV-2 drugs. Nsp3 is a large multi-spanning membrane protein, and its characterization in vitro has been challenging. Here we describe an in vitro assay to characterize the biochemical activity of full-length Nsp3 isolated from cells.
Christopher, Rainville +2 more
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Function and structure of rotavirus NSP3
2008International ...
Becker, Mm +6 more
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Getah virus Nsp3 binds G3BP to block formation of bona fide stress granules
International Journal of Biological MacromoleculesStress granules (SGs) are cytoplasmic aggregates of proteins and mRNA that form in response to diverse environmental stressors, including viral infections. Several viruses possess the ability to block the formation of stress granules by targeting the SGs marker protein G3BP.
Xiaoyi, Qi +8 more
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[Construction and expression of virus-like particles containing rotavirus NSP3 gene].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2014To construct and express ribonuclease-resistant virus-like particles containing rotavirus NSP3 gene by changing the affinity of MS2 bacteriophage coat protein pac site and to discuss the stability.In the study, 1 049 bp rotavirus NSP3 gene fragments were amplified by PCR using the primers containing PvuI and KpnI restriction enzyme sites and the ...
Le, Chang +5 more
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Characterization of SARS-CoV-2 protease NSP3 and NSP5 degradome.
Infectious diseases are serious threats to human health and economy in both developed and non-developed countries. They are the cause of approximately half of the death toll worldwide. Recently, a severe acute respiratory syndrome, named COVID-19 (coronavirus disease 2019), has spread across the globe and has been found to be caused by a novel strain ...openaire +1 more source