Results 81 to 90 of about 10,598 (216)

Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma

The Laryngoscope, EarlyView.
We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano, Satoshi Kiyama, Takayuki Kyutoku, Masaru Yamashita   +3 more
wiley   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Precision medicine in cancer: A comprehensive review of advanced cancer diagnosis technologies and personalized treatment strategies

Precision Medical Sciences, EarlyView.
The translational pipeline of precision medicine in clinical oncology. Schematic overview of the individualized cancer care workflow. (1) Input: Patient samples undergo multi‐omic profiling via NGS, single‐cell diagnostics, spatial maps, and epigenetic sequencing.
Asif Jan, Bushra Waheed, Rani Akbar, Daniel Dubwa   +3 more
wiley   +1 more source

Diagnosis and therapy of tumors with NTRK gene fusion

, 2021
NTRK-Genfusionen sind seltene genetische Alterationen, die tumorentitätenübergreifend vorkommen können. Während sie in den meisten soliden Tumoren nur sehr niederfrequent vorkommen, lassen sie sich in bestimmten Tumoren wie dem infantilen Fibrosarkom ...
Stenzinger, Albrecht, Reichardt, Peter, Bielack, Stefan S., Länger, Florian, Merkelbach-Bruse, Sabine, Seufferlein, Thomas, Tabatabai, Ghazaleh, Wörmann, Bernhard, Griesinger, Frank, Westphalen, Benedikt C., Weichert, Wilko, Loges, Sonja, Hummel, Michael, Vokuhl, Christian, Overkamp, Friedrich, Graf, Norbert, Heukamp, Lukas C., Tilburg, Cornelis M. van, Bokemeyer, Carsten, Ivanyi, Philipp, Klingebiel, Thomas, Scheer, Monika, Schirmacher, Peter, Hettmer, Simone   +23 more
core   +1 more source

Navigating Evidence Standards: Stakeholder Perspectives on External Controls and Randomization in Cancer Trials

Asia-Pacific Journal of Clinical Oncology, EarlyView.
While historically the ‘gold standard,’ the role of large‐scale RCTs is being increasingly challenged in the contemporary oncology research era. External controls represent an alternate method for generating evidence, though the perspectives of key stakeholders regarding their role in oncology are not well known.
Sarah E. Heynemann, Wendy L. Lipworth, Sue‐Anne McLachlan, Jennifer Philip, Tom John, Ian H. Kerridge   +5 more
wiley   +1 more source

Immunohistochemistry and next-generation sequencing for NTRK fusion detection in differentiated thyroid cancer of children, adolescents and young adults

Introduction: Pan-TRK immunohistochemistry staining can assess the protein expression from NTRK gene fusions. A little is known about its utility in differentiated thyroid cancer samples from children, adolescents, and young adults patients.
Rafael Reis Campos da-Matta, Fabio Hecht, Gabriel Jeferson Rodríguez Machado, Bruno da Silva Lisboa, Alexandre Rolim da-Paz, Leonardo Freitas Boaventura Rios, Juliana Lima von-Ammon, Ana Clara Oliveira Tosta Telles, Taíse Lima Cerqueira de-Oliveira, Fabyan Esberard de Lima Beltrão, Guilherme de Castro Lopes, Helton Estrela Ramos   +11 more
core   +1 more source

NTRK gene aberrations in triple‐negative breast cancer: detection challenges using IHC, FISH, RT‐PCR, and NGS

The Journal of Pathology: Clinical Research, 2023
Triple‐negative breast cancer (TNBC) is usually an aggressive disease with a poor prognosis and limited treatment options. The neurotrophic tyrosine receptor kinase (NTRK) gene fusions are cancer type‐agnostic emerging biomarkers approved by the Food and
Federica Zito Marino, Simona Buono, Marco Montella, Rosa Giannatiempo, Francesco Messina, Giovanni Casaretta, Grazia Arpino, Giulia Vita, Francesco Fiorentino, Luigi Insabato, Alessandro Sgambato, Michele Orditura, Renato Franco, Marina Accardo   +13 more
doaj   +1 more source

Gliomas with pleomorphic and pseudopapillary features (GPAP) are circumscribed tumors with targetable mutations, prolonged survival, and frequent tumor predisposition

Brain Pathology, EarlyView.
DNA methylation profiling identifies GPAP as a distinct circumscribed glioma with a characteristic expansive, multicystic radiological appearance, pleomorphic and pseudopapillary histology, a recognizable CNV profile, druggable molecular alterations, and recurrent cancer predisposition syndromes.
Alberto Picca, Valeria Barresi, Aude Trinquet, Luca Bertero, Lucia Nichelli, Guillaume Chotard, Michèle Bernier, Thomas Gareau, Salah Eddine Oussama Kacimi, Jaydutt Bhalshankar, Mathilde Filser, Julien Masliah‐Planchon, Marta Iollo, Henri Malaize, Bertrand Mathon, Luc Bauchet, Kifah Khouri, Besma Barka, Hélène Madry, Sabrina Rossi, Evelina Miele, Giuseppe Kenneth Ricciardi, Catherine Carpentier, Irina Coin, Marc Sanson, Mehdi Touat, Caroline Dehais, Alessia Pellerino, Roberta Rudà, Paola Cassoni, Valérie Rigau, Emmanuelle Uro‐Coste, Karima Mokhtari, Ahmed Idbaih, Patrick R. Benusiglio, Franck Bielle   +35 more
wiley   +1 more source

Efficient Identification of Patients With NTRK Fusions Using a Supervised Tumor-Agnostic Approach

The neurotrophic tropomyosin receptor kinase (NTRK) family gene rearrangements have been recently incorporated as predictive biomarkers in a "tumor-agnostic" manner.
Camacho, C., Conde Gallego, Esther, Saiz-Lopez, P., Boni, V., Molero, A., López-Ríos Moreno, Fernando, Plaza Hernández, José Carlos, Paz-Ares Rodríguez, Luis Gonzaga, Chantada, D., Suarez-Gauthier, A., Abad, M., Juaneda-Magdalena, L., Del Carmen, S., Teixido, C., Garcia-Toro, E., Rojo, F., Sanchez-Frias, M.E., Alonso, M., Regojo, R.M., Hernandez, S., Martinez, R.   +20 more
core   +1 more source

Estimating the Prognostic Value of the NTRK Fusion Biomarker for Comparative Effectiveness Research in The Netherlands [PDF]

Objectives: We evaluated the prognostic value of the neurotrophic tyrosine receptor kinase (NTRK) gene fusions by comparing the survival of patients with NTRK+ tumours with patients without NTRK+ tumours.
Vellekoop, Heleen, A Huygens, Simone, Dinjens, Winand N.M., Santi, Irene, M Versteegh, Matthijs, Mölken, Maureen Rutten van; id_orcid   +5 more
core   +1 more source