Results 151 to 160 of about 6,280 (278)

Hijacking or helping?-How political actors use the COVID-19 pandemic in the climate discourse to advocate their policy beliefs and preferences. [PDF]

Policy Sci
Kammerer M, Baker J, Fesenfeld LP, Maier M, Montfort S, Ingold K.   +5 more
europepmc   +1 more source

Proposal: A Comprehensive Approach to a Northeast Asia Nuclear Weapon-Free Zone -Summary-

, 2015
Proposal: A Comprehensive Approach to a Northeast Asia Nuclear Weapon-Free Zone -Summary-, pp.1-19; 2015technical ...
Umebayashi, Hiromichi, Suzuki, Tatsujiro, Hirose, Satoshi, Nakamura, Keiko   +3 more
core  

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

The Circadian Rhythm of Asthma Immune Metabolism. [PDF]

J Immunol Res
Lu M, Cheng F, Zhao X, Wang Z, Chen J, Zhang Y, Huang S, Zhang X, Liu Y, Yao W, Xue Z, Xue Z.   +11 more
europepmc   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Turning the EU's agricultural vision into environmental action: A performance-oriented CAP after 2027. [PDF]

Ambio
Heyl K, Garske B, Stubenrauch J, Ehlers K.   +3 more
europepmc   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation. [PDF]

Exp Mol Med
Liao Z, Huang C, Zhang L, Hu C, Wu Z, Bai Z, Li G, Zhou L, Wang N, Huangfu C, Ni Z, Shen P, Zhou W, Gao Y.   +13 more
europepmc   +1 more source

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

Advanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen, Dong Ding, Zengpeng Zheng, Xufeng Chen, Wenjing Li, Jiaxin Shen, Zhiwei Huang, Peng Tan, Junjie Bai, Xia Fang, Baofang Xing, Puyuan Hu, Linghao Xu, Haokai Yu, Yixi Wang, Zongzhe Jiang, Yang Long, Tiejun Zhou, Mingxin Ye, Yu Jiang, Aoyuan Cui, Hong Li, Qiurong Ding, Yong Xu, Yu Li, Weitong Su, Feng Shen, Chenlin Gao, Wenguang Fu   +28 more
wiley   +1 more source

Mechanisms underlying end-organ injury in sleep apnoea. [PDF]

Eur Respir J
Badran M, Cortese R, Gileles-Hillel A, Gozal D.   +3 more
europepmc   +1 more source