Results 151 to 160 of about 53,123 (272)

Assessment of Right Ventricular Adaptability to Pressure Overloading for Critical Therapeutic Decision-Making Processes. [PDF]

J Clin Med
Dandel M.
europepmc   +1 more source

Saccadic dysmetria and adaptation after lesions of the cerebellar cortex [PDF]

, 1999
Barash, S, Glickstein, M, Melikyan, A, Sivakov, A, Thier, P, Zhang, M   +5 more
core   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Overexpression of alcohol dehydrogenase 1 A inhibits the progress of triple negative breast cancer via Wnt/β-catenin signaling. [PDF]

Sci Rep
Su L, Qiao C, Luo J, Zhu B, Liu Y.
europepmc   +1 more source

Humanitarian Approach to Nuclear Abolition [PDF]

, 2015
Kurosawa, Mitsuru
core  

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long-term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets. [PDF]

J Anat
Szabó FP, Sigutova V, Schneider AM, Hoerder-Suabedissen A, Molnár Z.   +4 more
europepmc   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Reducing the Risks of Nuclear War. [PDF]

Public Health Rev, 2023
Abbasi K, Ali P, Barbour V, Bibbins-Domingo K, Olde Rikkert MGM, Haines A, Helfand I, Horton R, Mash B, Mitra A, Monteiro C, Naumova EN, Rubin EJ, Ruff T, Sahni P, Tumwine J, Yonga P, Zielinski C.   +17 more
europepmc   +2 more sources

Chromatin Remodulator CHD4: A Potential Target for Cancer Interception. [PDF]

Genes (Basel)
Goswami K, Venkatachalam K, Singh SP, Rao CV, Madka V.   +4 more
europepmc   +1 more source