Results 51 to 60 of about 599,347 (291)
BigData and computing challenges in high energy and nuclear physics [PDF]
Journal of Instrumentation, 2017 In this contribution we discuss the various aspects of the computing resource needs experiments in High Energy and Nuclear Physics, in particular at the Large Hadron Collider. This will evolve in the future when moving from LHC to HL-LHC in ten years from now, when the already exascale levels of data we are processing could increase by a further order ...
A. Klimentov +3 more
openaire +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Nickel Ion Induced Multistage Assembly of Th13 Cluster
Nature CommunicationsClusters have proven useful models to elucidate the correlation between macroscopic properties and microstructures. However, the actinide clusters still remain much less developed compared to the splendid and systematic works of other members of this ...
Kong-Qiu Hu +11 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Scientific ReportsAbu-Sannan Petroleum Area (ASPA) is situated in Egyptian Western Desert and presents a suitable site for oil exploration. This study aimed to evaluate the radiological hazards linked to technologically enhanced naturally occurring radioactive materials ...
Aya Abdelrazk +3 more
doaj +1 more source
Explorations of the viability of ARM and Xeon Phi for physics processing
, 2013 We report on our investigations into the viability of the ARM processor and the Intel Xeon Phi co-processor for scientific computing. We describe our experience porting software to these processors and running benchmarks using real physics applications ...
Abdurachmanov, David +11 more
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Origins and Impacts of High-Density Symmetry Energy
, 2016 What is nuclear symmetry energy? Why is it important? What do we know about it? Why is it so uncertain especially at high densities? Can the total symmetry energy or its kinetic part be negative?
Li, Bao-An
core +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source