Results 51 to 60 of about 118,356 (260)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Revisiting $$B_s \rightarrow PP$$ B s → P P and PV decays with contributions from $${\phi }_{B2}$$ ϕ B 2 with the perturbative QCD approach

European Physical Journal C: Particles and Fields
The $$B_s \rightarrow PP$$ B s → P P and PV decay modes are revisited at leading order within the perturbative QCD (pQCD) approach, incorporating the $$B_s$$ B s mesonic wave function (WF) $${\phi }_{B2}$$ ϕ B 2 .
Yueling Yang, Zhao-Jie Lü, Su-Ping Jin, Junfeng Sun   +3 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

The nonfactorizable QED correction to the $$\overline{B}_{s}$$ B ¯ s $${\rightarrow }$$ → $$D_{s}^{(*)} {\ell } \bar{\nu }_{\ell }$$ D s ( ∗ ) ℓ ν ¯ ℓ decays

European Physical Journal C: Particles and Fields
Considering the nonfactorizable QED corrections, the branching ratios and ratios of branching ratios $$R(D_{s}^{({*})})$$ R ( D s ( ∗ ) ) for the semileptonic $$\overline{B}_{s}$$ B ¯ s $${\rightarrow }$$ → $$D_{s}^{(*)} {\ell } \bar{\nu }_{\ell }$$ D s (
Yueling Yang, Jiazhi Li, Liting Wang, Junfeng Sun   +3 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Form factors of V′ → V″ transition within the light-front quark models

Journal of High Energy Physics, 2019
In this paper, we calculate the matrix element and form factors of vector-to- vector (V I → V II ) transition within the standard light-front (SLF) and covariant light- front (CLF) quark models (QMs), and investigate the self-consistency and Lorentz ...
Qin Chang, Li-Ting Wang, Xiao-Nan Li
doaj   +1 more source

Foundations of nuclear and particle physics

, 2017
This textbook brings together nuclear and particle physics, presenting a balanced overview of both fields as well as the interplay between the two.
T. William Donnelly, Donnelly, T William, Richard G. Milner, Milner, Richard G, Formaggio, Joseph A, Surrow, Bernd, Holstein, Barry R, Joseph A. Formaggio, Bernd Surrow, Barry R. Holstein   +9 more
core   +1 more source

Particle Physics Outreach to Secondary Education [PDF]

, 2011
This review summarizes exemplary secondary education and outreach programs of the particle physics community. We examine programs from the following areas: research experiences, high-energy physics data for students, informal learning for students ...
Young, M. Jean, Marjorie G. Bardeen, M. Jean Young, K. Erik, Johansson,, Bardeen, Marjorie G., Johansson, K. Erik, K. Erik Johansson   +6 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source