Results 71 to 80 of about 26,433,322 (295)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Uncertainty Analysis of Decay Heat Power after Fast Neutron Fission Based on Sensitivity/Uncertainty Method

Yuanzineng kexue jishu
To deal with the problem that notable light water reactor decay heat calculation standard is not suitable for fast reactor, this paper adopted the sensitivity/uncertainty (S/U) method to analyze the uncertainty introduced by nuclear data in the ...
WANG Fenglong1, YANG yong1, , HUANG Xiaolong2
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Trend Analysis of Criticality Benchmark Testing Results Based on Reaction Channel Sensitivity Using Apriori Algorithm

Yuanzineng kexue jishu
In recent years, machine learning algorithms have been extensively and successfully applied across multiple domains within nuclear physics, particularly demonstrating remarkable effectiveness in conducting trend analysis for the integral validation of ...
MA Yanhu, WU Haicheng, ZHANG Huanyu
doaj   +1 more source

Development of an automated platform for the verification, testing, processing and benchmarking of Evaluated Nuclear Data at the NEA Data Bank

EPJ Web of Conferences, 2016
Modern nuclear data Quality Assurance (QA) is, in practice, a multistage process that aims at establishing a thorough assessment of the validity of the physical information contained in an evaluated nuclear data file as compared to our best knowledge of ...
Michel-Sendis F., Díez C.J., Cabellos O.   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Experiments in the EXFOR library for evaluation of thermal neutron constants

EPJ Web of Conferences, 2017
E.J. Axton’s experimental database adopted in evaluation of thermal neutron constants by himself and also by a recent project to update the IAEA Neutron Standard was checked against the experimental literature and EXFOR library.
Otuka Naohiko, Capote Roberto, Semkova Valentina, Kawai Takuma, Noguere Gilles   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Nuclear data for ion beam analysis applications

EPJ Web of Conferences, 2017
Nuclear data for Ion Beam Analysis have been compiled and disseminated by the Nuclear Data Section through the Ion Beam Analysis Nuclear Data Library (IBANDL) for over a decade.
Dimitriou Paraskevi, Semkova Valentina, Zerkin Viktor   +2 more
doaj   +1 more source