Results 61 to 70 of about 1,424,034 (160)

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

European Nuclear Disarmament: a study of transnational social movement strategy [PDF]

, 2004
This thesis is a study of an attempt to help create a transnational movement against the nuclear arms race and the Cold War in the 1980s. The attempt began with the drafting and launch of the Appeal for European Nuclear Disarmament in early 1980.
Burke, P.D.M.
core   +1 more source

Disarmament, Demobilization, and Reintegration: The co-evolution of concepts, practices, and understanding [PDF]

, 2009
Programs for the Disarmament, Demobilization, and Reintegration (DDR) of ex-combatants have become more common as an element in the peacebuilder’s toolkit.
Kilroy, Walt
core   +2 more sources

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Brazil and the TPNW: Brazilian Interests and the Promotion of the Norm of Nuclear Prohibition [PDF]

Contexto Internacional
The Treaty on the Prohibition of Nuclear Weapons (TPNW) formalises the norm of nuclear prohibition and is presented as a way to fill a gap regarding nuclear disarmament.
Luiza Elena Januário, Raquel Gontijo
doaj   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, Volume 13, Issue 53, 24 September 2026.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Backing up nuclear disarmament [PDF]

Science, 2018
Who could have imagined the possibility of an inter-Korean Summit this year, let alone one between the United States and North Korea? Recent news that North Korea may suspend nuclear tests and dismantle its test site is a startling about-face, given the country's multitude of missile and nuclear weapons tests over the past decade.
openaire   +2 more sources

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source

Los problemas del desarme nuclear en la postguerra fría: Las naciones unidas y la conferencia de desarme en la década del noventa

Historia Actual On-Line, 2011
En este artículo se analiza el desarrollo del desarme nuclear y los pensamientos a favor de su realización definitivo en los noventas. El desarme estuvo bajo la dirección de las Naciones Unidas a través de la Conferencia de Desarme, el cual intentó la ...
Ana Tejo Carrasco
doaj   +2 more sources

Korean Peninsula Nuclear Challenges: The Imperative of Regional Cooperative Security Solutions

The Mongolian Journal of International Affairs, 2011
DOI: 10.5564/mjia.v0i14.27 Mongolian Journal of International Affairs No.14 2007 pp.71 ...
Wade L Huntley
doaj   +1 more source