Results 41 to 50 of about 749,092 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

High-Energy Lepton Scattering and Nuclear Structure Issues

, 2023
High-energy lepton scattering constitutes the focus of this study. Developments are provided to motivate the basic choices of kinematic variables for the particular case of semi-inclusive electron scattering where these variables are devised to match ...
Donnelly, Thomas W., Thomas W. Donnelly
core   +1 more source

A PROPOSAL OF PROCESS VALIDATION IN THE IMPLEMENTATION OF GOOD MANUFACTURING PRACTICES IN BRACHYTHERAPY SOURCES PRODUCTION

Brazilian Journal of Radiation Sciences, 2021
New laboratories for brachytherapy sources production are being implemented in our facility at IPEN, in São Paulo. A great challenge implementing a production laboratory is to comply with the Good Manufacturing Practices (GMPs), which involves process ...
Tatyana Spinosa Baptista, Anselmo Feher Feher, Bruna Teiga Rodriguez, Carlos Alberto Zeituni, João Augusto Moura, Maria Elisa Rostelato   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Calibration coefficients of epitaxial diodes used in diagnostic radiology and computed tomography beams

Brazilian Journal of Radiation Sciences
The assessment of the calibration coefficients of an epitaxial diode, previously characterized for diagnostic radiology (RQR qualities) and computed tomography (RQT qualities) dosimetry, is reported in this work. The diode, with an n-type epitaxial layer
Josemary A. C. Gonçalves, Patrícia de Lara Antonio, Linda V. E. Caldas, Carmen C. Bueno   +3 more
doaj   +1 more source

Determination of α+nucleus optical potential relevant for p-process study from the natIn(α, α) elastic scattering [PDF]

EPJ Web of Conferences
The knowledge of alpha optical potential is important for determining the nuclear reaction rates. natIn(α, α)natIn elastic scttering cross-sections have been measured at energies Elab = 26 and 29 MeV above the coulomb barrier.
Basak Dipali, Bar Tanmoy, Sahoo Lalit Kumar, Saha Sukhendu, Rana Tapan Kumar, Bhattacharya Chandana, Manna Santu, Kundu Samir, Sahoo Jayanta Kr, Meena Jaikiran, Saha Amiya Kr, Basu Chinmay   +11 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Direct determination of aluminum in low-enriched UAlx targets (UAlx-Al) by Inductively Coupled Plasma Optical Emission Spectrometry

Brazilian Journal of Radiation Sciences, 2021
The production of molybdenum-99 (99Mo) using low-enriched uranium targets (< 20% 235U) dispersed in aluminum (UAlx) is a very promising strategy towards the independence in 99Mo local production.
Sabine Neusatz Guilhen, Alexandre Luiz de Souza, Marycel Elena Barboza Cotrim, Maria Aparecida Faustino Pires   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source