Results 191 to 200 of about 6,649,887 (302)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States. [PDF]

Adv Sci (Weinh)
Dunton CL, Paola Gonzalez C, Almassalha L, Li WS, Gong R, Acosta N, Ye IC, Frederick J, Hogg C, John S, Williams JAG, Nap RJ, Szleifer I, Backman V.   +13 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Technical reviewers for Nuclear Engineering and Technology, 2022

Nuclear Engineering and Technology, 2022
doaj   +1 more source

Nuclear transport receptor importin 11 oppositely regulates viral and bacterial diseases in Nicotiana benthamiana. [PDF]

Plant Physiol
Zhuang X, Li T, Zhao Z, Tan J, Du X, Zhang Y, Qiu Y, Tian Z, Xu K.   +8 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

AI-Empowered Nuclear Medicine Education, Part 3: Practical AI Applications for Learners. [PDF]

J Nucl Med Technol
Jacobs KM, Peacock JG.
europepmc   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Technical reviewers for Nuclear Engineering and Technology, 2023

Nuclear Engineering and Technology, 2023
doaj   +1 more source

Metastasis-Specific <i>APC</i> Alteration and Nuclear β-Catenin Accumulation in IPMN-Associated Pancreatic Ductal Adenocarcinoma: Genomic Analysis of Matched Precursor, Carcinoma, and Liver Metastasis-A Case Report. [PDF]

J Clin Med
Woo CG, Jo K, Kim J, Kim EG, Lee OJ.
europepmc   +1 more source