Results 91 to 100 of about 663,366 (347)

The Imperative for Nuclear Responsibility: Facing the Weapons Legacy in School [PDF]

open access: yes, 1993
Nuclear industry\u27s pro-uranium mining campaign in Saskatchewan public ...
Regnier, Robert
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher   +10 more
wiley   +1 more source

Global Solutions vs. Local Solutions for the AI Safety Problem [PDF]

open access: yes, 2019
There are two types of artificial general intelligence (AGI) safety solutions: global and local. Most previously suggested solutions are local: they explain how to align or “box” a specific AI (Artificial Intelligence), but do not explain how to prevent ...
Turchin, Alexey
core  

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang   +10 more
wiley   +1 more source

Protocol for isolating nuclei from frozen fish heart tissue for single-cell genomic assays

open access: yesSTAR Protocols
Summary: Unbiased isolation of intact single nuclei from complex tissues, such as cryopreserved hearts, for massively parallel single-cell genomic assays is particularly challenging.
Chaoguang Wei   +5 more
doaj   +1 more source

Energy options from the 20th Century: Comparing Conventional and Nuclear Energy from a Sustainable Standpoint

open access: yesJournal of Natural Resources and Development, 2012
Different Energy options have been the driving force for the world economy with an evolution in types and sources. Decades ago choosing what energy option to use did not call for much debate as issues of sustainability, pressure on our environment, and ...
Eric Ndeh Mboumien Ngang
doaj   +1 more source

The birth of roboethics [PDF]

open access: yes, 2005
The importance, and urgency, of a Roboethics lay in the lesson of our recent history. Two of the front rank fields of science and technology, Nuclear Physics and Genetic Engineering, have already been forced to face the ethical consequences of their ...
Veruggio, Gianmarco
core  

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

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