Results 141 to 150 of about 429,890 (312)

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

E-LENS: User Requirements-Oriented AI Ethics Assurance [PDF]

arXiv
Despite the much proliferation of AI ethical principles in recent years, there is a challenge of assuring AI ethics with current AI ethics frameworks in real-world applications. While system safety has emerged as a distinct discipline for a long time, originated from safety concerns in early aircraft manufacturing.
arxiv  

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

Tesla's Autopilot: Ethics and Tragedy [PDF]

arXiv
This case study delves into the ethical ramifications of an incident involving Tesla's Autopilot, emphasizing Tesla Motors' moral responsibility. Using a seven-step ethical decision-making process, it examines user behavior, system constraints, and regulatory implications.
arxiv  

Ultra‐Shallow Flat Heat Waves on Low Thermal Conductivity Flexible Polyimide Substrate for Millisecond Thermal Analysis of Materials and Bioelectronic Applications

Advanced Engineering Materials, EarlyView.
An electronic system is presented consisting of a silver thin‐film electrode on a polyimide substrate working both as a heating element and a resistive temperature sensor, generating millisecond heat pulses with very fast heating and cooling rates and a flat peak temperature with a tunable duration.
Bahman K. Boroujeni, Jan Frede, Simon T. Herrmann, Natalie Heinen, Hans Kleemann, Stephanie Pfaender   +5 more
wiley   +1 more source

Protocol for the purification and analysis of nuclear UFMylated proteins

STAR Protocols
Summary: Protein UFMylation regulates numerous cellular processes including ribosome quality control and nuclear DNA repair. Here, we present a technique to isolate nuclei and purify UFMylated proteins under denaturing non-reducing conditions from ...
Pudchalaluck Panichnantakul, Marlene Oeffinger   +1 more
doaj  

A Workflow‐Centric Approach to Generating FAIR Data Objects for Computationally Generated Microstructure‐Sensitive Mechanical Data

Advanced Engineering Materials, Volume 27, Issue 8, April 2025.
A novel metadata schema is introduced to address the sparsity of microstructure‐sensitive mechanical data. The design follows the material modeling workflow, as each run results in the definition of unique data objects. The schema includes categorical elements to ensure findability, accessibility, interoperability, and reusability (FAIR). This approach
Ronak Shoghi, Alexander Hartmaier
wiley   +1 more source

Enhanced Mechanical Properties of Injectable Chitosan–Guar Gum Hydrogel Reinforced with Bacterial Cellulose Nanofibers for Tissue Engineering Applications

Advanced Engineering Materials, EarlyView.
This study presents the development and characterization of injectable nanocomposite hydrogels based on N‐succinyl chitosan, oxidized guar gum, and bacterial cellulose nanofibers. Emphasizing enhanced mechanical properties and biocompatibility, the hydrogels exhibit fast gelation, improved structural integrity, and reduced swelling. Their potential for
Raimundo Nonato Fernandes Moreira Filho, Pascale Chevallier, Silvia Rodriguez Fernandez, Maud Viallon, Matheus Xavier de Oliveira, Ana Lorena de Brito Soares, Diego Mantovani, Judith Pessoa de Andrade Feitosa, Rodrigo Silveira Vieira   +8 more
wiley   +1 more source

Robust Systemic and Mucosal Immune Responses to Coxsackievirus B3 Elicited by Spider Silk Protein Based Nanovaccines via Subcutaneous Immunization

Advanced Functional Materials, Volume 35, Issue 15, April 10, 2025.
Spider minor ampullate silk protein (MiSp) and retinoic acid (RA) based nanovaccine are capable of eliciting both mucosal and systemic immune responses following subcutaneous administration and demonstrate significant protective effects against CVB3 infection in mice.
Xingmei Qi, Guoqiang Wei, Yanan Li, Sidong Xiong, Gefei Chen   +4 more
wiley   +1 more source

A Novel Protein‐Polysaccharide Oral Nanoemulsion Targeting Activated Hepatic Stellate Cells to Enhance the Therapeutic Effect of Pirfenidone on Fibrosis After Transarterial Chemoembolization for Liver Cancer

Advanced Functional Materials, EarlyView.
Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng, Shan Xu, Yi Lei, Huizhou He, Runbin Sun, Xingle Jin, Cheneryu Huang, Yuhao Zheng, Jianqing Peng, Lei Tang, Peng Luo, Yi Chen, Shuai Zhang   +12 more
wiley   +1 more source