Results 271 to 280 of about 2,696,237 (374)

Iridium complex-loaded biomimetic vesicles enable enhanced photodynamic therapy and immune modulation. [PDF]

Microsyst Nanoeng
Xiaohui Z, Xuelin T, Bai L, Zhao R, Chen Y, Tian X.   +5 more
europepmc   +1 more source

Human Cloning and \u3cem\u3eDonum Vitae\u3c/em\u3e [PDF]

, 1999
Lozano, Alexander J.
core   +1 more source

Ethics, Nuclear Terrorism, and Counter-Terrorist Nuclear Reprisals – A Response to John Mark Mattox's 'Nuclear Terrorism: The Other Extreme of Irregular Warfare'

, 2015
Thomas E. Doyle
openalex   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

Risk perception of the radiation health effects of decommissioning workers at Fukushima Daiichi Nuclear Power Plant. [PDF]

J Radiat Res
Matsunaga H, Zabirowa A, Liu M, Kashiwazaki Y, Orita M, Hande V, Takamura N.   +6 more
europepmc   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Uncoupling protein 2 and signal transducer and activator of transcription 1 are targets of human papillomavirus oncoproteins and may be prognostic markers for cervical cancer development. [PDF]

Front Oncol
Beldi MC, Colunna FC, Lorenzi NP, Lasso Larco JA, Sichero L, Baracat EC, Lino VS, Boccardo E, Mota G, Villa LL, Tacla M, Kamilos MF, Genta MLND, Lepique AP.   +13 more
europepmc   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Tanshinone IIA alleviates LPS-induced acute kidney injury by inhibiting RIP3/Nrf2-mediated oxidative stress. [PDF]

Ren Fail
Zhang S, Dong X, Chen G, Wang C.
europepmc   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source