Results 51 to 60 of about 663,366 (347)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Ethics and Nuclear Energy

Zbornik Pravnog fakulteta Sveučilišta u Rijeci, 2001
Should the scientist be a morally unbiased person? This is the eternal question asked by many great thinkers interested in science. The answer is hard to find. Scientists are expected to take into consideration the consequences of their actions before they actually start to act.
Nežić, Nadalina, Dodig, Damir
openaire   +2 more sources

Nuclear Weapons and In-Group Moral Reasoning: The Case of Orthodox Christianity

Journal for Peace and Nuclear Disarmament
Are nuclear weapons moral? The contemporary ban movement asserts that they are not, and a common view prevails that even if possession for deterrence can be accepted, there is a taboo against the use of nuclear weapons.
Christopher Ferrero
doaj   +1 more source

After Fukushima: The precautionary principle revisited

Verbum et Ecclesia, 2012
Etienne de Villiers, more than other theologians, elaborates on basic elements of a Christian ethics of responsibility. He distinguishes between retrospective and prospective responsibility.
Wolfgang Huber
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Protocol for imaging nuclear pore complexes on isolated nuclei of zebrafish early embryos by field emission scanning electron microscopy

STAR Protocols, 2023
Summary: Here, we present a protocol to observe the three-dimensional surface of nuclear pore complexes (NPCs) of vertebrate early embryos by field emission scanning electron microscopy (FESEM).
Weimin Shen, Anming Meng
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Protocol for live-cell super-resolution imaging of transport of pre-ribosomal subunits through the nuclear pore complex

STAR Protocols
Summary: Here, we present a protocol for single-molecule super-resolution imaging of the nuclear export of pre-ribosomal subunits pre-40S and pre-60S through nuclear pore complexes. We describe steps for plating cells and co-transfecting cells.
Mark Tingey, Samuel L. Junod, Coby Rush, Weidong Yang   +3 more
doaj   +1 more source

Evaluation of Urine Polymerase Chain Reaction Test Positivity Rates and the Effectiveness of Positron Emission Tomography in Renal Involvement in Patients with Active COVID-19 Infection: A Prospective and Multidisciplinary Study

Haseki Tıp Bülteni, 2021
Aim:It is known that the Coronavirus disease-2019 (COVID-19) does not only affect the respiratory system in the body, but also affects many vital systems.
Turev Demirtas, Gokhan Sonmez, Omur Mustafa Parkan, Ahmet Tutus, Zeynep Ture, Sevket Tolga Tombul, Orhan Yildiz, Selma Gokahmetoglu, Emrah Kizilay, Abdullah Demirtas   +9 more
doaj   +1 more source

Internet Surveys by Direct Mailing: An Innovative Way of Collecting Data [PDF]

, 1997
This article describes a new method of collecting data by direct mailing via the Internet. Feasibility and capacities were evaluated through a worldwide opinion poll on global future risks of mankind and potential solutions.
Dillman, D.A., Frey, J.H., Nikolai Mühlberger, Rolf Weitkunat, Sebastian Schneeweiß, The Internet Society., Walter J. Swoboda   +6 more
core   +1 more source