Results 121 to 130 of about 4,295,257 (299)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Yantu gongcheng xuebaoTo study the effects of shallowly buried explosion cratering occurring near the silo, three centrifugal model tests are conducted using the geotechnical centrifuge ZJU400 at Zhejiang University.
ZHAO Fengkui 1, 2, GUAN Longhua 1, ZHANG Dezhi 3, LU Qiang 3, ZHU Bin 1, 2, WANG Yubing 1, 2,
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Progress in constraining the asymmetry dependence of the nuclear caloric curve
EPJ Web of Conferences, 2016 The nuclear equation of state is a basic emergent property of nuclear material. Despite its importance in nuclear physics and astrophysics, aspects of it are still poorly constrained.
McIntosh Alan B., Yennello Sherry J.
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NuPECC Survey on Experimental Nuclear Physics: Outlook for a Nuclear Physics Career in Europe
Nuclear Physics is considered as a very important community in Physics, particularly in Europe. However, this qualitative statement requires some quantitative backing. How many nuclear physicists are there in Europe? Where do they work? What do they work
Ramos, Inés Gómez +1 more
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Nuclear Regulatory Commission Report NUREG-0491
, 1978 From introduction: This Safety Evaluation Report summarizes the results of the technical evaluation of the proposed RESAR-414 design performed by the NRC staff, and delineates the scope of the technical matters considered in evaluating the radiological ...
U.S. Nuclear Regulatory Commission. Office of Nuclear Reactor Regulation.
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source