Results 21 to 30 of about 1,328,128 (231)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Today and Future Neutrino Experiments at Krasnoyarsk Nuclear Reactor

, 1999
The results of undergoing experiments and new experiment propositions at Krasnoyarsk underground nuclear reactor are presentedComment: 4 ...
A.A. Sabelnikov, A.V. Cherny, A.V. Martemyanov, Davis, Derbin, E.V. Turbin, G.A. Shishkina, I.N. Machulin, Kozlov, L.A. Popeko, Oakley, S.V. Khalturstsev, V.G. Tarasenkov, V.N. Vyrodov, V.P. Martemyanov, Voloshin, Vyrodov, Yu.V. Kozlov   +17 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

A suggested search for 207Pb nuclear Schiff moment in PbTiO3 ferroelectric

, 2005
We suggest two types of experiments, NMR and macroscopic magnetometry, with solid PbTiO3 to search for the nuclear Schiff moment of 207Pb. Both kinds of experiments promise substantial improvement over the presently achieved sensitivities.
A. Abragam, C. P. Slichter, D. Suter, I. B. Khriplovich, J. S. Kim, O. P. Sushkov, O. P. Sushkov, O. P. Sushkov, R. Tycko, T. N. Mukhamedjanov, V. V. Flambaum   +10 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

World experience in nuclear steam reheat [PDF]

, 2011
Concepts of nuclear reactors cooled with water at supercritical pressures were studied as early as the 1950s and 1960s in the USA and Russia. After a 30-year break, the idea of developing nuclear reactors cooled with SuperCritical Water (SCW) became attractive again as the ultimate development path for water cooling.
Igor Pioro, Eugene Saltanov
openaire   +5 more sources

Nuclear resonant scattering experiment with fast time response: new scheme for observation of $^{229\rm m}$Th radiative decay

, 2017
Nuclear resonant excitation of the 29.19-keV level in $^{229}$Th with high-brilliance synchrotron- radiation and detection of its decay signal, are proposed with the aim of populating the extremely low-energy isomeric state of $^{229}$Th.The proposed ...
Hara, H., Hiraki, T., Kasamatsu, Y., Kitao, S., Kobayashi, Y., Konashi, K., Masuda, R., Masuda, T., Miyamoto, Y., Okai, K., Okubo, S., Ozaki, R., Sasao, N., Sato, O., Schumm, T., Seto, M., Shigekawa, Y., Stellmer, S., Suzuki, K., Uetake, S., Watanabe, M., Yamaguchi, A., Yasuda, Y., Yoda, Y., Yoshimi, A., Yoshimura, K., Yoshimura, M.   +26 more
core   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source