Results 121 to 130 of about 35,158 (311)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Targeted elimination of molybdenum ions from a leaching solution with the ability of radiated grafting GMA-PAN nanofibers

Scientific Reports
In this study, electrospun polyacrylonitrile nanofibers were effectively functionalized for enhanced molybdenum ion adsorption through a multi-step approach.
Mohammad Reza Fayazi, Mohammad Outokesh, Mehdi Asadollahzadeh, Meisam Torab-Mostaedi, Rezvan Torkaman   +4 more
doaj   +1 more source

Glassy carbon formation from pyrolysis of polymeric coatings on fiber-optic sensors

Materials & Design
Deploying fiber-optic sensors in nuclear reactors requires a detailed understanding of radiation effects on the fiber materials and the transmitted signals.
Bryan Conry, J. Matthew Kurley, Daniel C. Sweeney, Christian M. Petrie   +3 more
doaj   +1 more source

A PWR Self- Contained Actinide Transmutation System

, 2006
Elements of the new Global Nuclear Energy Partnership (GNEP) initiative in the US call for the expansion of domestic use of nuclear power and the minimization of nuclear waste.
Shatilla, Y., Kazimi, Mujid S., Hejzlar, Pavel   +2 more
core  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Regional Examples of Geological Settings for Nuclear Waste Disposal in Deep Boreholes

, 2010
This report develops and exercises broad-area site selection criteria for deep boreholes suitable for disposal of spent nuclear fuel and/or its separated constituents.
Sapiie, B., Driscoll, Michael J., Jensen, K. G.   +2 more
core  

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

A Systematic Study of Moderation Effects On Neutronic Performance of UO[subscript 2] Fueled Lattices

, 2001
This report addresses the physics of reactor cores that can be operated for 10 to 15 years without refueling — inspired by the objective of enhanced nuclear fuel cycle performance with regard to economics and resistance to weapon proliferation ...
Kazimi, Mujid S., Xu, Z., Driscoll, Michael J.   +2 more
core  

Modeling the Nuclear Fuel Cycle [PDF]

, 2005
The Advanced Fuel Cycle Initiative is developing a system dynamics model as part of their broad systems analysis of future nuclear energy in the United States. The model will be used to analyze and compare various proposed technology deployment scenarios.
Jacobson, Jacob J., Yacout, A. M., Moisseytsev, A., Piet, S. J., Matthern, G. E.   +4 more
core  

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source