Results 51 to 60 of about 79,655 (259)

The Potential of Pressurised Water Reactors to Provide Flexible Response in Future Electricity Grids

Energies, 2020
The electricity market is undergoing significant change with the increasing deployment of Variable Renewable Energy Sources (VRES) and the adoption of policies to electrify transport, heating and industry, which will continue to increase demands on all ...
Aiden Peakman, Bruno Merk, Kevin Hesketh
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Neutronics analysis of the ion cyclotron resonance heating antenna of the China Fusion Engineering Test Reactor

Nuclear Engineering and Technology
Ion cyclotron resonance heating (ICRH) is an important auxiliary heating method applied to the China Fusion Engineering Test Reactor, which can effectively heat the ions and electrons in plasma.
Gaoxiang Wang, Chengming Qin, Shanliang Zheng, Yongsheng Wang, Kun Xu, Huiqiang Ma   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Numerical study on PWR fuel rod cladding ballooning and burst behavior with the thermo-mechanical coupling finite element method

International Journal of Advanced Nuclear Reactor Design and Technology
The ballooning behavior of fuel rod cladding is an important issue of nuclear reactor, which may initiate a severe nuclear reactor accident. Based on COMSOL multi-physical module, this research established a thermo-mechanical coupling finite element ...
Xin Zhang, Gen Li, Runhua Gao, Xinhai Zhao, Peitao Yao   +4 more
doaj   +1 more source

Experimental study on the dynamic mechanical behaviors of silicon carbide ceramic after thermal shock

Nuclear Materials and Energy, 2020
As a potential substitute material for metal and concrete in producing nuclear waste storage canisters, silicon carbide (SiC) can be subjected to various mechanical and thermal influences during its lifetime. To investigate the reliability of SiC in situ,
Xiang Li, Kai Zhang, Heinz Konietzky, Yan Wang, Xibing Li   +4 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

A study on increase of vapor in PWR steam generator (Improvement of heat transfer coefficient by fin and twisted tape introduction)

Nihon Kikai Gakkai ronbunshu, 2016
Increasing the electric power of nuclear power plant is important for the economy and the environment. Pressurized water reactor (PWR) exchanges the heat of primary system with secondary system in the steam generator (SG) to generate vapor. In this study,
Kenta FUJI, Shinichi MOROOKA
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source