Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan +6 more
wiley +1 more source
The Range and the Mean Free Path of High Energy Nucleons in Nuclear Matter [PDF]
, 1950 Y. Fujimoto, Y. Yamaguchi
openalex +1 more source
In-medium effective chiral lagrangians and the pion mass in nuclear matter [PDF]
, 1995 We argue that the effective pion mass in nuclear matter obtained from chiral effective lagrangians is unique and does not depend on off-mass-shell extensions of the pion fields as e.g. the PCAC choice. The effective pion mass in isospin symmetric nuclear
Thorsson, Vesteinn, Wirzba, Andreas
core +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
The Effect of Exclusion Principle on the Nucleon-nucleon Scattering in Nuclear Matter [PDF]
, 1951 Y Yamaguchi
openalex +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Thirring: DIE GESCHICHTE DER ATOMBOMBE/de Broglie: L'OPTIQUE ELECTRONIQUE/Slater: MICROWAVE TRANSMISSION/Lindsay: AN INTRODUCTION TO PHYSICAL STATISTICS/Bergmann: INTRODUCTION TO THE THEORY OF RELATIVITY/Reichenbach: PHYLOSOPHIC FOUNDATIONS OF QUANTUM MECHANICS/Bridgman: THE NATURE OF THERMODYNAMICS/Dunning und Paxton: MATTER, ENERGY, AND RADIATION/Fermi: NUCLEAR PHYSICS/Lemon und Ferrence: ANALYTICAL EXPERIMENTAL PHYSICS/Gamow: THE BIRTH AND DEATH OF THE SUN/„DER ANFANG ODER DAS ENDE?”︁ [PDF]
, 1947 Geschichte Die +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Modeling Nuclear Pasta and the Transition to Uniform Nuclear Matter with the 3D Skyrme-Hartree-Fock Method at Finite Temperature I: Core-Collapse Supernovae [PDF]
arXiv, 2009 The first results of a new three-dimensional, finite temperature Skyrme-Hartree-Fock+BCS study of the properties of inhomogeneous nuclear matter at densities and temperatures leading to the transition to uniform nuclear matter are presented. Calculations are carried out in a cubic box representing a unit cell of the locally periodic structure of the ...
arxiv