Results 31 to 40 of about 455,210 (249)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Neutron nuclear data measurements for criticality safety

EPJ Web of Conferences, 2017
To support the US Department of Energy Nuclear Criticality Safety Program, neutron-induced cross section experiments were performed at the Geel Electron Linear Accelerator of the Joint Research Center Site Geel, European Union.
Guber Klaus, Paradela Carlos, Heyse Jan, Kopecky Stefan, Schillebeeckx Peter, Siegler Peter   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

In-Pile Qualification of the Fast-Neutron-Detection-System

EPJ Web of Conferences, 2018
In order to improve measurement techniques for neutron flux assessment, a unique system for online measurement of fast neutron flux has been developed and recently qualified in-pile by the French Alternative Energies and Atomic Energy Commission (CEA) in
Fourmentel D., Villard J-F., Destouches C., Geslot B., Vermeeren L., Schyns M.   +5 more
doaj   +1 more source

3D-printed scaffold harboring copper ions combined with near-infrared irradiation for local therapy of cancer

iScience, 2023
Summary: Cancer is a major health threat and a leading cause of human death worldwide. Surgical resection is the primary treatment for most cancers; however, some patients develop locoregional recurrence.
Hao Wei, Dong Chen, Bin Han, Peng Li, Hao Jia, Lizhang Zhu, Hao Yang, Deren Lan, Wei Wei, Haibo Chen, Yongxiang Luo, Yongsheng Zhao   +11 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gamma-based nuclear fusion measurements at inertial confinement fusion facilities

Frontiers in Physics, 2022
Experiments performed on an inertial confinement fusion (ICF) platform offer a unique opportunity to study nuclear reactions, including reaction branches that are useful for diagnostic applications in ICF experiments as well as several that are relevant ...
Z. L. Mohamed, Y. Kim, J. P. Knauer
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Exclusive measurements of nuclear breakup reactions of 17Ne

EPJ Web of Conferences, 2014
We have studied one-proton-removal reactions of about 500MeV/u 17Ne beams on a carbon target at the R3B/LAND setup at GSI by detecting beam-like 15O-p and determining their relative-energy distribution.
Wamers F., Marganiec J., Aksouh F., Aksyutina Yu., Álvarez-Pol H., Aumann T., Beceiro-Novo S., Bertulani C.A., Boretzky K., Borge M.J.G., Chartier M., Chatillon A., Chulkov L.V., Cortina-Gil D., Egorova I.A., Emling H., Ershova O., Forssén C., Fraile L.M., Fynbo H., Galaviz D., Geissel H., Grigorenko L.V., Heil M., Hoffmann D.H.H., Hoffmann J., Johansson H., Jonson B., Karagiannis C., Karakoç M., Kiselev O.A., Kratz J.V., Kulessa R., Kurz N., Langer C., Lantz M., Larsson K., Bleis T. Le, Lemmon R., Litvinov Yu.A., Mahata K., Müntz C., Nilsson T., Nociforo C., Nyman G., Ott W., Panin V., Parfenova Yu.L., Paschalis S., Perea A., Plag R., Reifarth R., Richter A., Rodriguez-Tajes C., Rossi D., Riisager K., Savran D., Schrieder G., Shul’gina N.B., Simon H., Stroth J., Sümmerer K., Taylor J., Tengblad O., Tengborn E., Weick H., Wimmer C., Zhukov M.V.   +67 more
doaj   +1 more source

Precision long-term measurements of beta-decay-rate ratios in a controlled environment

Physics Letters B, 2017
We report on measurements of relative beta-decay rates of Na-22, Cl-36, Co-60, Sr-90, Cs-137 monitored for more than one year. The radioactive samples are mounted in an automated sample changer that sequentially positions the five samples in turn, with ...
S.D. Bergeson, J. Peatross, M.J. Ware
doaj   +1 more source