Results 61 to 70 of about 1,806,326 (359)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Germanium Detector Response to Nuclear Recoils in Searching for Dark Matter [PDF]

, 2012
The discrepancies in claims of experimental evidence in the search for weakly interacting massive particle (WIMP) dark matter necessitate a model for ionization efficiency (the quenching factor) at energies below 10 keV. We have carefully studied the physics processes that contribute to the ionization efficiency through stopping power.
arxiv   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Current Induced Nuclear Spin Depolarization at Landau Level Filling Factor nu=1/2 [PDF]

Physical Review B 86, 115421 (2012), 2012
Hyperfine interactions between electron and nuclear spins in the quantum Hall regime provide powerful means for manipulation and detection of nuclear spins. In this work we demonstrate that significant changes in nuclear spin polarization can be created by applying an electric current in a 2-dimensional electron system at Landau level filling factor nu=
arxiv   +1 more source

The Impact of China’s Investment in Nuclear Energy on the Reputation of Nuclear Power and the World’s Energy Supply [PDF]

, 2014
Over the past ten years, China’s involvement in nuclear power has increased dramatically. The country has seemingly unlimited resources to build nuclear power centers and has no qualms about using these resources.
Mattson, Laura
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Passivity-Based Control of Buck-Boost Converter for Different Loads Research

Journal of Electrical and Computer Engineering, 2023
Normally, the buck-boost converter adopts single or double closed-loop control, and there are differences in control and parameters for different working modes and loads.
Feng Zhang, Jianguo Li, Gejun Zhu, Rongyuan Hu, Yaping Qu, Yujiang Zhang   +5 more
doaj   +1 more source

Enhancing Electron-Nuclear Resonances by Dynamical Control Switching [PDF]

arXiv, 2023
We present a general method to realize resonant coupling between spins even though their energies are of different scales. Applying the method to the electron and nuclear spin systems such as a nitrogen-vacancy (NV) center with its nearby nuclei, we show that a specific dynamical switching of the electron spin Rabi frequency achieves efficient electron-
arxiv  

Pathways towards the nuclear revival in Finland, France, and the UK [PDF]

, 2010
Nuclear power is undergoing a revival in a number of countries of both developed and developing world, and is increasingly presented as a solution to the problems of climate change and energy security.
Lehtonen, Markku, Martiskainen, Mari
core