Results 61 to 70 of about 667,555 (320)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

open access: yesMolecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou   +13 more
wiley   +1 more source

Development and Application of Reverse Lancing Equipment for the Secondary Side of Steam Generator in Nuclear Power Plants

open access: yesZhongguo dianli, 2020
It is absolutely necessary to expand high pressure lancing area in order to ensure the operation safety of steam generator transfer heat tubes in nuclear power plants.
Weirang WU   +4 more
doaj   +1 more source

Plasma‐activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high‐grade serous ovarian cancer cells

open access: yesMolecular Oncology, EarlyView.
High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies   +9 more
wiley   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

open access: yesMolecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park   +6 more
wiley   +1 more source

Enhancing Electron-Nuclear Resonances by Dynamical Control Switching [PDF]

open access: yesarXiv, 2023
We present a general method to realize resonant coupling between spins even though their energies are of different scales. Applying the method to the electron and nuclear spin systems such as a nitrogen-vacancy (NV) center with its nearby nuclei, we show that a specific dynamical switching of the electron spin Rabi frequency achieves efficient electron-
arxiv  

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

Resonance-like nuclear processes in solids: 3rd and 4th order processes [PDF]

open access: yesarXiv, 2013
It is recognized that in the family of heavy charged particle and electron assisted double nuclear processes resonance-like behavior can appear. The transition rates of the heavy particle assisted 3rd-order and electron assisted 4th-order resonance like double nuclear processes are determined. The power of low energy nuclear reactions in $Ni-H$ systems
arxiv  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Study on control rod worth measurement technique under deep subcritical condition

open access: yesHe jishu
BackgroundIn a series of startup physics tests, measuring the control rod worth is a critical means to determine whether the actual worth of the control rods matches the design values. This test ensures that the reactivity of the reactor can be precisely
SI Shengyi   +6 more
doaj   +1 more source

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