Results 61 to 70 of about 376,302 (266)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Perspectives on nuclear power

Energy Policy
This study reassesses the role of nuclear power in low-carbon electricity transitions under prevailing cost, finance, and system conditions. Using harmonised international data and observed 2024 operational metrics, we conduct a modelling-based stress test that evaluates how nuclear power performs when realistic construction, financial, and flexibility
Jens Weibezahn, Björn Steigerwald, Arman Aghahosseini, Christian von Hirschhausen, Mark Z. Jacobson, Christian Breyer   +5 more
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Preparation of a Platinum-Coated Copper and its Adsorption Performance on Gaseous Iodine

Journal of Isotopes
To develop efficient and easily recoverable iodine adsorbent materials，a platinum coated copper (PCC) material coated with platinum on the surface of copper powder was prepared and used for the adsorption of gaseous iodine.
Bo LI, Shibin LI, Chang LIU, Ning LUO, Fu XUE, Yunming CHEN, Jinsong ZHANG   +6 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

DFT study on the mechanism of manganese(II)-catalyzed destruction of oxalic acid in nitric acid systems

Journal of Saudi Chemical Society
In the plutonium purification cycle of the PUREX process, the decomposition process in nitric acid systems is critical for the treatment of oxalic acid in the post-nuclear fuel reprocessing.
Lei Li, Xiaoteng Zhang, Zixuan Liu, Siwen Yuan, Xuefeng Hou, Yantao Hu, Sifan Li, Ran Jia, Jian Wang, Jing Ma   +9 more
doaj   +1 more source

Research on the Preparation of Irradiated-type 99Mo-99mTc Generator

Journal of Isotopes
Due to the excellent nuclear properties，99mTc has been used in the field of early diagnosis of tumor and nuclear medicine imaging. As the most widely applied radioisotope，it accounts for more than 70% of the market of total radioisotopes used in the ...
Siwei GU, Ning LUO, Bo LI, Qinzhi LI, Yingjiang HU, Yunming CHEN, Jinsong ZHANG   +6 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Research Progress in the Preparation Technology of Radium-223

Journal of Isotopes
223Ra is a low toxicity substance α Radiotherapy nuclide, which can be used to treat castrated resistant prostate cancer (CRPC) with symptoms of bone metastasis and no visceral metastasis, was the first approved alpha therapy radiopharmaceutical on the ...
Junshan GENG, Jianrong WU, Qian XIAO, Bo LI, Yunming CHEN, Jingsong ZHANG, Ning LUO   +6 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source