Results 111 to 120 of about 446,429 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Siting nuclear power plants in California: the near-term alternatives [PDF]

, 1973
There are many issues presently being debated concerning the generation and utilization of electric power in California. Some are peculiar to a specific area, such as the level of air quality and how it is influenced by fossil-fuel power plants.
Goldsmith, Martin
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Development of earthquake instrumentation for shutdown and restart criteria of the nuclear power plant using multivariable decision-making process

Nuclear Engineering and Technology, 2018
This article presents a new design of earthquake instrumentation that is suitable for quick decision-making after the seismic event at the nuclear power plant (NPP).
Md M. Hasan, Joyce K. Mayaka, Jae C. Jung   +2 more
doaj   +1 more source

The Paks Nuclear Power Plant: scientific inventions - practical applications [PDF]

, 1999
A fair question may be what lessons and messages a presentation of a nuclear power plant that was conceptualized in the sixties-seventies and commissioned in the eighties tan provide.
Katona, Tamás János
core  

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Knowledge-Driven Claim Governance: A Checklist of Entitlements and Procedures in FIDIC and National Standard Contracts

Buildings
Claims are a significant cause of delays and increased costs in international construction projects, yet contract provisions on claims remain inconsistent, narrative, and difficult to apply in practice.
Hweeho Cho, Wooyong Jung, Chan Young Park   +2 more
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

137Cs and 90Sr in the water of the ChNPP cooling pond [PDF]

Ядерна фізика та енергетика, 2014
Results of long-term observations on 137Cs and 90Sr concentration in water mass of the ChNPP Cooling Pond are presented. Drastic transformation of the intrinsic trend in changes with time of averaged radionuclides con-tent in water is clearly ...
V. V. Kanivets, S. I. Kireev, G. V. Laptev, O. I. Nasvit, S. M. Obrizan   +4 more
doaj  

After heat distribution of a mobile nuclear power plant [PDF]

A computer program was developed to analyze the transient afterheat temperature and pressure response of a mobile gas-cooled reactor power plant following impact.
Parker, W. G., Tang, Y. S., Vanbibber, L. E.   +2 more
core   +1 more source