Results 91 to 100 of about 7,292,547 (369)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Recent developments in the eikonal description of the breakup of exotic nuclei

, 2015
The study of exotic nuclear structures, such as halo nuclei, is usually performed through nuclear reactions. An accurate reaction model coupled to a realistic description of the projectile is needed to correctly interpret experimental data.
Capel, P., Colomer, F., Esbensen, H., Fukui, T., Johnson, R. C., Nunes, F. M., Ogata, K.   +6 more
core   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Recent Developments in the Experimental Nuclear Reaction Data Library EXFOR

, 2014
The International Network of Nuclear Reaction Data Centres (NRDC) provides nuclear reaction data services to users through collection and compilation of experimental nuclear reaction data in the EXFOR database.
V. Semkova, N. Otuka, S. Simakov, V. Zerkin   +3 more
semanticscholar   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Scattering cross section for various potential systems

Nuclear Engineering and Technology, 2017
We discuss the problems of scattering in this framework, and show that the applied method is very useful in the investigation of the effect of the resonance in the observed scattering cross sections.
Myagmarjav Odsuren, Kiyoshi Katō, Gonchigdorj Khuukhenkhuu, Suren Davaa   +3 more
doaj   +1 more source

Measurements at low energies of the polarization-transfer coefficient Kyy' for the reaction 3H(p,n)3He at 0 degrees

, 1997
Measurements of the transverse polarization coefficient Kyy' for the reaction 3H(p,n)3He are reported for outgoing neutron energies of 1.94, 5.21, and 5.81 MeV.
Gould, C. R., Hale, G. M., Huffman, P. R., Keith, C. D., Roberson, N. R., Tornow, W., Wilburn, W. S.   +6 more
core   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Analysis of the excitation function of deuteron induced nuclear reaction on Neon-20 using COMPLET code [PDF]

Nuclear Energy and Technology
In this study deuteron induced nuclear reaction on 20Ne target was studied to get nuclear information about 18F and 21Na radioisotopes which are widely used in medical and nuclear reactor technologies respectively.
Guadie Degu Belete, Yihunie Hibstie Asres, Senamaw Mequanent Zegeye, Yesigat Enawugaw Alemu   +3 more
doaj   +3 more sources