Results 91 to 100 of about 775,419 (311)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Towards many-body based nuclear reaction modelling

EPJ Web of Conferences, 2016
The increasing need for cross sections far from the valley of stability poses a challenge for nuclear reaction models. So far, predictions of cross sections have relied on more or less phenomenological approaches, depending on parameters adjusted to ...
Hilaire Stéphane, Goriely Stéphane
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Nuclear data measurements at the upgraded neutron time-of-flight facility n_TOF at CERN

, 2015
Applications of nuclear data like neutron-induced reaction cross sections are related to research fields as stellar nucleosynthesis, the study of nuclear level densities and strength functions, and also play a key role in the safety and criticality ...
Calviani, M., Bosnar, D., Billowes, J., Barros, S., Bečvář, F., Weiss, Christina, Kavrigin, P., Bécares, V., Leeb, Helmut, Bacak, Michael, Berthoumieux, E., Barbagallo, M., Beinrucker, C., Caamaño, M., Griesmayer, Erich, Brugger, M., Calviño, F., Andrzejewski, J., Belloni, F., Jericha, Erwin; orcid:, Audouin, L., Žugec, P., Gunsing, F., Balibrea-Correa, J., Aberle, O.   +24 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Microscopic derivation of the interacting boson model parameters with machine learning

Physics Letters B
Machine learning is applied to derive microscopically parameters of the interacting boson model for nuclear spectroscopy. A physics-guided neural network is proposed, which is trained to map the potential energy landscapes that are calculated within the ...
Y. Obata, K. Nomura
doaj   +1 more source

NUCLEAR REACTIONS AND NUCLEAR STRUCTURE

Acta Physica Sinica, 1962
This article reviews the methods of studying the nuclear structure by means of the nuclear reaction as a tool for investigation. It is divided into two parts. The first part is mainly concerned with the properties of the individual low-lying levels of nuclei, a brief outline being given to describe the present situation of cumulation of experimental ...
openaire   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Demo 25-15 Mousetrap Chain Reaction

, 2001
An array of mousetraps, each loaded with two Ping-Pong balls, is used as the classic model of an uncontrolled nuclear chain reaction, as seen in Figure 1 just as the device is fired.

core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source