Results 161 to 170 of about 7,324,154 (387)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

Effect of compound nuclear reaction mechanism in 12C(Li6,d) reaction at sub-Coulomb energy

open access: yesPhysics Letters B, 2017
The angular distribution of the 12C(Li6,d) reaction populating the 6.92 and 7.12 MeV states of 16O at sub-Coulomb energy (E=cm3 MeV) are analysed in the framework of the Distorted Wave Born Approximation (DWBA).
Ashok Mondal, S. Adhikari, C. Basu
doaj   +1 more source

Dynamics of Damped Nuclear Reactions [PDF]

open access: yesPhysica Scripta, 1983
The nucleon-exchange model for damped nuclear reactions is briefly reviewed in the framework of macroscopic transport theory. Recent developments are discussed and some future directions indicated.
openaire   +3 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

C12+12C fusion S⁎-factor from a full-microscopic nuclear model

open access: yesPhysics Letters B, 2021
The C12+12C fusion reaction plays a vital role in the explosive phenomena of the universe. The resonances in the Gamow window rule its reaction rate and products.
Yasutaka Taniguchi, Masaaki Kimura
doaj  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

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