Results 71 to 80 of about 416,600 (294)

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan, Ya‐Fang Chen, Cheng‐Hsuan Li, Yih‐Chih Kuo, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Tai‐Chung Tseng, Tung‐Hung Su, Chien‐Ting Hsu, Huey‐Ling Chen, Chin‐Hsien Lin, Yen‐Hsuan Ni   +12 more
wiley   +1 more source

Nuclear Uncertainties Associated with the Nucleosynthesis in Ejecta of a Black Hole Accretion Disk

The Astrophysical Journal
The simulation of heavy element nucleosynthesis requires input from yet-to-be-measured nuclear properties. The uncertainty in the values of these off-stability nuclear properties propagates to uncertainties in the predictions of elemental and isotopic ...
Matthew R. Mumpower, Trevor M. Sprouse, Jonah M. Miller, Kelsey A. Lund, Jonathan Cabrera Garcia, Nicole Vassh, Gail C. McLaughlin, Rebecca Surman   +7 more
doaj   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Low-metallicity Nova Explosions: A Site for Weak rp-process Nucleosynthesis

The Astrophysical Journal
Classical novae are common cataclysmic events involving a binary system of a white dwarf and a main-sequence or red giant companion star. In metal-poor environments, these explosions produce ejecta differently from their solar counterparts due to the ...
Athanasios Psaltis, Jordi José, Richard Longland, Christian Iliadis   +3 more
doaj   +1 more source

Short-range correlations in dynamical intranuclear cascade models for describing nucleon knockout reactions

Physics Letters B
Spallation and fragmentation reactions at incident energies above the Fermi momentum are considered to be the main mechanism for the production of neutron-rich nuclei at worldwide nuclear physics facilities, such as RIBF, FRIB, and GSI-FAIR.
J.L. Rodríguez-Sánchez, J. Cugnon, J.C. David, J. Hirtz   +3 more
doaj   +1 more source

Calculation of Neutron Induced Nuclear Reaction on Deuteron with Faddeev Equation

Yuanzineng kexue jishu, 2022
Neutron induced nuclear reaction on light nuclei is an important subject in nuclear data research. The reaction of the n+d three nucleons system is also an important platform for examining the nucleonnucleon interaction theories.
LI Yan;PANG Danyang;CHEN Wendi;TAO Xi;XU Ruirui;GE Zhigang
doaj  

Re-estimation of 180Ta nucleosynthesis in light of newly constrained reaction rates

Physics Letters B, 2019
Recent measurements of the nuclear level densities and γ-ray strength functions below the neutron thresholds in 180,181,182Ta are used as input in the nuclear reaction code TALYS.
K.L. Malatji, M. Wiedeking, S. Goriely, C.P. Brits, B.V. Kheswa, F.L. Bello Garrote, D.L. Bleuel, F. Giacoppo, A. Görgen, M. Guttormsen, K. Hadynska-Klek, T.W. Hagen, V.W. Ingeberg, M. Klintefjord, A.C. Larsen, P. Papka, T. Renstrøm, E. Sahin, S. Siem, L. Siess, G.M. Tveten, F. Zeiser   +21 more
doaj   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Neutron-induced cross sections of short-lived nuclei via the surrogate reaction method

EPJ Web of Conferences, 2011
The measurement of neutron-induced cross sections of short-lived nuclei is extremely difficult due to the radioactivity of the samples. The surrogate reaction method is an indirect way of determining cross sections for nuclear reactions that proceed ...
Morel P., Gaudefroy L., Faul T., Daugas J.M., Bauge E., Burke J.T., Czajkowski S., Companis I., Capellan N., Barreau G., Mathieu L., Aïche M., Roig O., Méot V., Jurado B., Boutoux G., Pillet N., Romain P., Taieb J., Théroine C., Derkx X., Sérot O., Matea I., Tassan-Got L., Gunsing F.   +24 more
doaj   +1 more source