Results 171 to 180 of about 2,950,431 (303)

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Electrochemical Electron Transfer: Key Concepts, Theories, and Parameterization via Atomistic Simulations. [PDF]

Chem Rev
Zhang M, Chen Y, Melander MM, Huang J.
europepmc   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Acute complications of nuclear medicine: an emergency medicine perspective. [PDF]

EJNMMI Res
Sutaşır MN, Arslan B, Mohamed MM, Hökenek NM.   +3 more
europepmc   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source

Identification of MNT fragments produced by an energy-degraded 238 U beam on a 209 Bi target at the FRS Ion Catcher. [PDF]

Eur Phys J A Hadron Nucl
Shraier A, Constantin P, Dickel T, Mardor I, Mollaebrahimi A, Amanbayev D, Andrés SAS, Bergmann J, Ge Z, Haettner E, Kar D, Kripko-Koncz G, Kumar D, Mahajan K, Morrissey DJ, Narang M, Plaß WR, Scheidenberger C, Simonov M, Tortorelli N, Yu J, Ahokas J, Amorim B, Bagchi S, Bajzek M, Balabanski DL, Botsiou K, Charviakova V, Eronen T, Glöckner S, Hornung C, Hubbard N, Jaries A, Kalantar-Nayestanaki N, Kankainen A, Karmakar A, Lozeva R, Rodríguez-Sánchez JL, Mitsiou I, Reiter MP, Piasetzky E, Piau V, Podolyák Z, Prajapat R, Prajapati D, Purushothaman S, Reponen M, Rocco E, Ruotsalainen J, Kostyleva D, Singh SK, Spătaru A, State A, Stefănescu I, Tanaka YK, Trache L, Welde L, Zhao J.   +57 more
europepmc   +1 more source

Elevated liver enzymes is not an impediment to allopurinol dose escalation: an observational cohort study

Arthritis Care &Research, Accepted Article.
Objective Routine liver enzyme monitoring is advocated while on allopurinol but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzymes in gout patients commenced on allopurinol. Methods 150 patients with gout and normal baseline serum aminotransferases initiated on allopurinol were followed ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Ultrafast bimolecular reaction catalysis via engineered nuclear quantum effects in helium nanodroplets. [PDF]

Nat Commun
Chen J, Zhao L, Huang H, Ye Z, Hu Y, Shi M, Long X, Sanz-Sanz C, Roncero O, Liu L, Li X, Ni H, Li Z, Zhang W, Wu J.   +14 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source