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Androgen receptor acts as the transcriptional repressor of the nuclear receptor LRH-1 via the androgen-driven chromatin looping conformation in prostate cancer. [PDF]
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Oxysterols and nuclear receptors
Molecular and Cellular Endocrinology, 2019Oxysterols are derivatives of cholesterol and an important regulator of cholesterol metabolism, in part due to their role as ligands for nuclear receptors, such as the liver X receptors. Oxysterols are also known to be ligands for the RAR-related orphan receptors, involved in normal T cell differentiation.
Liqian Ma, Erik R. Nelson
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Bioinformatics of Nuclear Receptors
2003Publisher Summary This chapter reviews the information that biologists interested in nuclear receptors can get by using a computer, including general resources and those specialized in nuclear receptors, whether for accessing data or analyzing it.
Marc, Robinson-Rechavi, Vincent, Laudet
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Current Opinion in Cell Biology, 1997
Retinoic acid, steroid and thyroid hormones regulate complex programs of gene expression by binding to intracellular receptors that are members of the nuclear receptor superfamily of ligand-dependent transcription factors. Recent studies have led to the identification and cloning of genes encoding coactivator molecules that appear to play important ...
C K, Glass, D W, Rose, M G, Rosenfeld
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Retinoic acid, steroid and thyroid hormones regulate complex programs of gene expression by binding to intracellular receptors that are members of the nuclear receptor superfamily of ligand-dependent transcription factors. Recent studies have led to the identification and cloning of genes encoding coactivator molecules that appear to play important ...
C K, Glass, D W, Rose, M G, Rosenfeld
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Annual Review of Entomology, 2012
The nuclear receptors (NRs) of metazoans are an ancient family of transcription factors defined by conserved DNA- and ligand-binding domains (DBDs and LBDs, respectively). The Drosophila melanogaster genome project revealed 18 canonical NRs (with DBDs and LBDs both present) and 3 receptors with the DBD only.
Susan E, Fahrbach +2 more
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The nuclear receptors (NRs) of metazoans are an ancient family of transcription factors defined by conserved DNA- and ligand-binding domains (DBDs and LBDs, respectively). The Drosophila melanogaster genome project revealed 18 canonical NRs (with DBDs and LBDs both present) and 3 receptors with the DBD only.
Susan E, Fahrbach +2 more
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Ubiquitination of nuclear receptors
Clinical Science, 2017Nuclear receptors (NRs) are cellular proteins, which upon ligand activation, act to exert regulatory control over transcription and subsequent expression. Organized via systemic classification into seven subfamilies, NRs partake in modulating a vast expanse of physiological functions essential for maintenance of life.
Jimmy, El Hokayem +3 more
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Nuclear Receptors in Energy Metabolism
2022Nuclear receptors are master regulators of energy metabolism through the conversion of extracellular signals into gene expression signatures. The function of the respective nuclear receptor is tissue specific, signal and co-factor dependent. While normal nuclear receptor function is central to metabolic physiology, aberrant nuclear receptor signaling ...
Walth-Hummel, A.A., Herzig, S., Rohm, M.
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Annals of the New York Academy of Sciences, 2007
Abstract: Nuclear receptors (NRs) represent a class of ligand‐dependent and ‐independent transcription factors with importance to the regulation of development, reproduction, and metabolism. The emergence of new understanding of the structure, function, and role in disease of NRs provides new insights into the interaction between genetics and the ...
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Abstract: Nuclear receptors (NRs) represent a class of ligand‐dependent and ‐independent transcription factors with importance to the regulation of development, reproduction, and metabolism. The emergence of new understanding of the structure, function, and role in disease of NRs provides new insights into the interaction between genetics and the ...
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Nuclear receptors and disease: androgen receptor
Essays in Biochemistry, 2004The androgen receptor (AR) protein regulates transcription of certain genes. Usually this depends upon a central DNA-binding domain that permits the binding of androgen–AR complexes to regulatory DNA sequences near or in a target gene. The AR also has a C-terminal ligand-binding domain and an Nterminal transcription modulatory domain.
Bruce, Gottlieb +4 more
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Nuclear receptors in disease: the oestrogen receptors
Essays in Biochemistry, 2004For several decades, it has been known that oestrogens are essential for human health. The discovery that there are two oestrogen receptors (ERs), ERalpha and ERbeta, has facilitated our understanding of how the hormone exerts its physiological effects.
Maria, Nilsson +2 more
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