Results 141 to 150 of about 30,972 (212)

Network‐based allosteric analysis of galectin‐7: Key residues dictate functional communication and stability

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Allosteric modulation enables precise control of protein activity but remains difficult to harness for selective inhibitor design. Traditional high‐throughput screening for allosteric modulators is still costly and time‐consuming, underscoring the need for predictive computational approaches.
N. T. Hang Pham, Alex Paré, Myriam Létourneau, Marlène Fortier, David Chatenet, Yves St‐Pierre, Patrick Lagüe, Charles Calmettes, Nicolas Doucet   +8 more
wiley   +1 more source

Molecular Identification of <i>HR97</i> in the Swimming Crab <i>Portunus trituberculatus</i> and Its Potential Involvement in Ovarian Development. [PDF]

Biology (Basel)
Hou D, Bao Y, Chen Y, Zhou Q, Zhu X, Xie X, Zhu D.   +6 more
europepmc   +1 more source

Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Azathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy—combining network toxicology, machine learning, Mendelian randomization (MR), and molecular docking—to elucidate the biological basis of AZA ...
Zhijun Xie, Hang Lei, Pengcheng Zhang, Zhi Li, Wenfu Tang   +4 more
wiley   +1 more source

Patterns of Composition, Richness and Endemicity of Cyperaceae Across Open and Closed Habitats in Madagascar's Central Highlands

Biotropica, Volume 58, Issue 2, March 2026.
We assessed Cyperaceae species composition, richness and endemicity across closed (forest), dry open (dry grasslands, rocky outcrops, bare dry soils), and wet open (marshes, swamps, wet grasslands, riparian areas) habitats in Isalo National Park and the Itremo Massif Protected Area, both in Madagascar's Central Highlands.
Fitiavana Rasaminirina, Jakub D. Wieczorkowski, Vonjison Rakotoarimanana, Valisoa Louisicaël Rafaralahy, Nivohenintsoa Rakotonirina, Hélène Ralimanana, Isabel Larridon   +6 more
wiley   +1 more source

<p>KMO downregulation promotes hepatocellular carcinoma growth via 3‑HAA‑mediated mitochondrial mass and function imbalances</p>. [PDF]

Int J Oncol
Liu M, Zhang X, Hu Y, Niu L, Guo L, Zhao G, Lu F, Jia F, Li L, Wu H, Zhu J.   +10 more
europepmc   +1 more source

Investigation of the mechanism of Yijing Decoction in the treatment of premature ovarian insufficiency: A network pharmacology study. [PDF]

Biochem Biophys Rep
Xu Y, Zhao X, Yu W, Zhang P, Cheng Z, Yang L, Zhou H.   +6 more
europepmc   +1 more source

GhSTH‐2 Integrates Host Redox Signalling and Effector Recognition and Confers Resistance Against Verticillium dahliae in Cotton

Molecular Plant Pathology, Volume 27, Issue 3, March 2026.
The fungal effector VdEPG1, secreted by Verticillium dahliae, interacts with the PR10/Bet v1‐like protein GhSTH‐2. This interaction activates GhSTH‐2‐mediated enhancement of cotton disease resistance through GhTXNDC9‐dependent ROS signalling, while simultaneously enabling VdEPG1 to suppress GhSTH‐2‐induced immunogenic necroptosis.
Siyu Zhang, Jinglong Zhou, Zili Feng, Feng Wei, Lihong Zhao, Yalin Zhang, Heqin Zhu, Hongjie Feng   +7 more
wiley   +1 more source

Structural basis for diosgenin as an inverse agonist of retinoic acid receptor-related orphan receptor γ. [PDF]

Sci Rep
Chen S, Tian S, Liang J, Wang R, Li Y.
europepmc   +1 more source

The maize mitogen‐activated protein kinase kinase kinase gene ZmMAPKKK45 is associated with multiple disease resistance

New Phytologist, Volume 249, Issue 6, Page 3003-3020, March 2026.
Summary Southern leaf blight (SLB), caused by the necrotrophic fungus Cochliobolus heterostrophus, is a major foliar disease of maize (Zea mays) world‐wide. A genome‐wide association study was performed to dissect the genetic basis of SLB resistance in maize. Functional validation was performed using mutant and transgenic analyses.
Tao Zhong, Bode Olukolu, Yang Bian, Shang Xue, Randall J. Wisser, Peter S. Ojiambo, James B. Holland, Qin Yang, Peter Balint‐Kurti   +8 more
wiley   +1 more source

Cortisol as a factor contributing to the development of non-alcoholic fatty liver disease in severely obese patients: a single-center prospective study. [PDF]

Arch Med Sci Atheroscler Dis
Constantinopoulos P, Georgoulia G, Theofanis G, Antzoulas A, Litsas D, Papadopoulos PD, Liolis E, Leventis P, Kornaros N, Leivaditis V, Mulita F, Skroubis G.   +11 more
europepmc   +1 more source