Results 61 to 70 of about 515,216 (272)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Dissociation of relativistic $^{10}$C nuclei in nuclear track emulsion

, 2011
Dissociation of 1.2 A GeV $^{10}$C nuclei in nuclear track emulsionis is studied. It is shown that most precise angular measurements provided by this technique play a crucial role in the restoration of the excitation spectrum of the 2$\alpha$+2p system.
D. A. Artemenkov, D. O. Krivenkov, D.A. Artemenkov, D.A. Artemenkov, D.A. Artemenkov, K. Z. Mamatkulov, M.I. Adamovich, N. K. Kornegrutsa, N.G. Peresadko, P. I. Zarubin, P.A. Rukoyatkin, R. R. Kattabekov, R. Stanoeva, R.R. Kattabekov, S. S. Alikulov, V.V. Belaga   +15 more
core   +1 more source

A scintillating plastic fiber tracking detector for neutron and proton imaging and spectroscopy [PDF]

, 1999
We report the results of recent calibration data analysis of a prototype scintillating fiber tracking detector system designed to perform imaging, spectroscopy and particle identification on 20 to 250 MeV neutrons and protons.
Castaneda, Carlos, Cutlip, Hansford H, Li, Wenhui, Macri, John R, McConnell, Mark L, Messner, Richard A, Romero, Juan L, Ryan, James M., Zheng, Quihua   +8 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Electromagnetic dissociation of relativistic $^8$B nuclei in nuclear track emulsion

, 2009
Experimental data on fragmentation channels in peripheral interactions of $^8$B nuclei in nuclear track emulsions are presented. A detailed analysis made it possible to justify selections of events of the electromagnetic-dissociation process $^8$B $\to^7$
A. D. Kovalenko, A. I. Malakhov, C. A. Bertulani, D. A. Artemenkov, D. A. Artemenkov, D. Cordina-Gil, D. O. Krivenkov, G. Baur, G. Baur, G. I. Orlova, I. G. Zarubina, L. A. Goncharova, M. H. Smedberg, M. Haiduc, M. I. Adamovich, M. M. Chernyavsky, N. A. Kachalova, N. G. Peresadko, N. G. Polukhina, N. Iwasa, N. P. Andreeva, P. A. Rukoyatkin, P. A. Rukoyatkin, P. I. Zarubin, R. Stanoeva, R. Stanoeva, S. P. Kharlamov, S. Vokál, T. Aumann, T. V. Shchedrina, V. Bradnova, V. V. Rusakova   +31 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Study of pollution in the El Jadida-Safi Atlantic coastal zone (Morocco) by using PIXE and SSNTD methods [PDF]

, 2008
In this work PIXE experiments were performed for measuring heavy and light elements (ranging from aluminium to lead) concentrations inside various polluted and unpolluted soils as well as liquid samples collected from different phosphate factory sewers ...
C. Ramboz, Campbell, Cohen, Gama, H. Erramli, H.D. Gogon, Johansson, Johansson, M.A. Misdaq, Misdaq, Misdaq, Owers, T. Sauvage, USEPA Report, Zine   +14 more
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of Heat Treatment on the Bulk Etch Rate Activation Energy of CR-39 Detector [PDF]

Kirkuk Journal of Science, 2016
The aim of this paper is to study the effect of heat treatment on the bulk etch rate activation energy (EB) of the nuclear track detector CR-39 at thermal heating of 145 °C for 20 min .
Ahmed A. I. AL-Obedy, Nada M. Hassan
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source