Results 41 to 50 of about 418,889 (263)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Heat transfer performance of high temperature and high velocity hydrogen flow and analysis of blockage characteristics

International Journal of Advanced Nuclear Reactor Design and Technology, 2022
In the current situation of increasing demand for nuclear heat propulsion in various countries, the heat transfer characteristics of high temperature and high velocity fluid in the flow channel are particularly important for safe core operation and ...
Wenxuan Ju, Xianmin Dong, Ruibo Lu, Haoran Shen, Fulong Zhao, Sichao Tan   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

CFD modeling of passive autocatalytic recombiners*

Nukleonika, 2015
This study deals with numerical modeling of passive autocatalytic hydrogen recombiners (PARs). Such devices are installed within containments of many nuclear reactors in order to remove hydrogen and convert it to steam.
Orszulik Magdalena, Fic Adam, Bury Tomasz   +2 more
doaj   +1 more source

Influence of the Metal Surface Texture on the Possibility of Controlling the Phase Transition of Water Droplets in the Single-Phase Regime

Applied Sciences, 2022
We experimentally studied the influence of the texture of copper and steel surfaces on the possibility of controlling the phase transition of water droplets in the single-phase regime.
Dmitriy Glushkov, Evgeniya Orlova, Anastasia Islamova, Dmitriy Nikitin, Yuriy Lyulin, Dmitriy Feoktistov   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The economics of organellar gene loss and endosymbiotic gene transfer

Genome Biology, 2021
Background The endosymbiosis of the bacterial progenitors of the mitochondrion and the chloroplast are landmark events in the evolution of life on Earth.
Steven Kelly
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Investigation on the Performance of a Wickless-Heat Pipe Using Graphene Nanofluid for Passive Cooling System

Atom Indonesia, 2019
To enhance the thermal safety in case of station blackout, a wickless-heat pipe is proposed as an alternative passive cooling system technology to remove decay heat generation in the nuclear spent fuel storage pool. The objectives of this research are to
M.H. Kusuma, N. Putra, A. Rosidi, S. Ismarwanti, A.R. Antariksawan, T. Ardiyati, M. Juarsa, T.M.I. Mahlia   +7 more
doaj   +1 more source