Results 181 to 190 of about 3,326,409 (352)

Índia e Paquistão

open access: yesMeridiano 47, 2017
O presente artigo busca analisar a atual situação conflituosa entre Paquistão e India, ambos detentores de armamentos nucleares.
João Fábio Bertonha
doaj  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Humanitarian and public health efforts are needed to eradicate nuclear weapons

open access: yesAustralian and New Zealand Journal of Public Health, 2012
Tilman Ruff, Ira Helfand
doaj   +1 more source

Universitas Polemologi dan Perang Terakhir [PDF]

open access: yes, 1984
: This article discusses the problem of war among men which at present in the form of nuclear warfare constitutes the greatest threat against humanity and the human ecosystem. In the present state of evolution of the arms race $25 000 per second is spent
T.Jacob
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

The Spectre of Nuclear Weapons Use in Ukraine: The Nuances of Nuclear War Risk

open access: yesGüvenlik Stratejileri Dergisi
The essence of Russian security policy is composed of the combined use of conventional and unconventional threats in both war and peacetime. Russia aims to dominate the process of escalation especially by frequently threatening nuclear war in Ukraine. It
Barış Çağlar
doaj   +1 more source

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