Results 31 to 40 of about 522,946 (185)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Canadian Contributions to the Manhattan Project and Early Nuclear Research [PDF]
arXiv, 2021 During the second world war, Canada made several important contributions to the wartime work of the Manhattan Project. The three main contributions were: establishing a domestic nuclear research laboratory in Montreal to investigate heavy water reactors, creating supply chains to provide uranium oxide, heavy water and polonium to the Manhattan Project,
arxiv
Don’t Talk About Your Fallout Shelter: Civilian Perceptions of Threat and Structural Responses during the Cold War in Regina, Saskatchewan between 1958 and 1963 [PDF]
, 2019 During the Cold War, the Canadian government initiated a civil defence campaign urging private citizens to construct shelters to protect themselves from the effects of nuclear fallout.
Mushynsky, Julie
core +1 more source
FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
Nuclear Imminence in Contemporary Indo‐Pakistani Conflict [PDF]
, 2009 November of 2008 saw frightening attacks on India’s foreigners. Over the course of three days, hostages had been taken, hotels and restaurants in India’s busiest city of Mumbai were burned and English, American and Canadian citizens lay among the nearly ...
Tobin, Anna K.
core
FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source
The President and Nuclear Weapons: Authorities, Limits, and Process [PDF]
, 2019 There is no more consequential decision for a president than ordering a nuclear strike. In the Cold War, the threat of sudden nuclear annihilation necessitated procedures emphasizing speed and efficiency and placing sole decision-making authority in the ...
DeRosa, Mary B., Nicolas, Ashley
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FEBS Letters, Volume 599, Issue 7, Page 952-970, April 2025.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, Volume 599, Issue 8, Page 1146-1158, April 2025.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
Letter from Joan Cook, Church and Society Commission of the National Council of Churches in New Zealand, to Geraldine Ferraro [PDF]
, 1984 Letter from Joan Cook, acting secretary of the Church and Society Commission of the National Council of Churches in New Zealand, to Geraldine Ferraro.
Cook, Joan, Ferraro, Geraldine
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