Results 31 to 40 of about 48,980 (246)
Threats by artificial intelligence to human health and human existence
BMJ Global Health, 2023 While artificial intelligence (AI) offers promising solutions in healthcare, it also poses a number of threats to human health and well-being via social, political, economic and security-related determinants of health.
David McCoy +4 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Nuclear-Crisis Management and Cyber War—A Dangerous Crossroads
, 2022 States’ actual experience in managing nuclear crises occurred almost entirely prior to the information age. The rule book for nuclear-crisis management in this era of cyber deterrence and cyber war remains to be written.
Cimbala, Stephen J.
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Nuclear War in the Rivalry Phase of the Modern World-System
Journal of World-Systems Research, 2018 Large-scale war is a world-system phenomenon of the rivalry phase. Such conflicts have once again become a concern, and nuclear weapons make these prospects especially dangerous.
Robert A. Denemark
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Episode 6: Contemplating the Unthinkable: Making Nuclear Deterrence Credible
, 2023 Synopsis:U.S. national security ultimately rests on its nuclear capabilities to deter existential challenges to its existence, alongside the commitment to use such weapons if other forms of deterrence have failed.
National Security Affairs Department, U.S. Naval War College
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Nuclear weapons: the state of play [PDF]
, 2013 The Crawford School of Public Policy’s Centre for Nuclear Non-Proliferation and Disarmament (CNND) this week launched in Geneva a major book-length report authoritatively documenting the unhappily diminishing global enthusiasm for nuclear disarmament ...
Ramesh Thakur, Gareth Evans
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