Results 171 to 180 of about 238,006 (379)

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
ABSTRACT The cytosine (C) modifications 5‐methylcytosine (mC) and 5‐hydroxymethylcytosine (hmC) are central regulatory elements of mammalian genomes. Both marks occur in double‐stranded DNA in either strand‐symmetric or ‐asymmetric fashion, but it is still poorly understood how this symmetry information is selectively read out by the nuclear proteome ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

Bubble Dynamics for Nucleate Pool Boiling of Water, Ethanol and Methanol Pure Liquids under the Atmospheric Pressure

Journal of Applied Fluid Mechanics, 2015
Bubble dynamics is the most important sub-phenomenon, which basically affects the nucleate pool boiling heat transfer coefficient. In this research, bubble departure diameter values were experimentally measured for heat fluxes up to 110 kW.m-2 ...
samane hamzekhani, Majedeh Maniavi Falahieh, Mohammad Rasoul Kamalizadeh, Mohammad Salmaninejad   +3 more
doaj  

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Microlayer evaporation during bubble growth in nucleate boiling

International Journal of Heat and Mass Transfer
C. Tecchio, B. Cariteau, Corentin Le Houedec, G. Bois, Elie Saikali, G. Zalczer, S. Vassant, Pere Roca i Cabarrocas, P. Bulkin, J. Charliac, V. S. Nikolayev   +10 more
semanticscholar   +1 more source

Flow boiling with enhancement devices for cold plate coolant channel design [PDF]

The effects of enhancement devices on flow boiling heat transfer in circular coolant channels, which are heated over a fraction of their perimeters, are studied.
Boyd, Ronald D., Smith, Alvin, Turknett, Jerry C.   +2 more
core   +1 more source

Heat flux correlation models for spray evaporative cooling of vibrating surfaces in the nucleate boiling region

, 2020
Alireza Sarmadian, J.F. Dunne, C.A. Long, J. Thalackottore Jose, Jean-Pierre Pirault, Cédric Rouaud   +5 more
openalex   +2 more sources

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Self-assembled foam-like graphene networks formed through nucleate boiling. [PDF]

Sci Rep, 2013
Ahn HS, Jang JW, Seol M, Kim JM, Yun DJ, Park C, Kim H, Youn DH, Kim JY, Park G, Park SC, Kim JM, Yu DI, Yong K, Kim MH, Lee JS.   +15 more
europepmc   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source